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首页 > 医学词汇大全 > Nodular fasciitis
Nodular fasciitis

骨科

关键词骨科 疾病 临床疾病

词汇介绍

拓展阅读

解析

Nodular     /'nɑdʒəlɚ/ 

         adj.  结节的;结节状的

同根词     nodule  n. 结节;小结 

         Objective of the report is to describe a case of nodular localized primary cutaneous amyloidosis (NLPCA).

本报告的目的是描述1例结节性限局性原发性皮肤淀粉样变性。

 

Fasciitis   /,fæʃɪ'aɪtɪs/ 

          n.[]  筋膜炎

同根词     fascia  /'feɪʃɪə; -ʃə/   /'feʃə/  n. 筋膜 

         Nodular fasciitis was negative staining for calponin, while positive for laminin.

与结节性筋膜炎相比,后者不表达钙调蛋白,而表达层粘连蛋白。

概述

一、疾病概述或定义早在1955年,美国病理学家Konwaler等首次描述了一种良性的、但组织学上令人惊恐的病变,当时被称为“皮下组织的假肉瘤样纤维瘤病”(筋膜炎),这是种纤维母细胞的结节性增生。此后许多作者将相似的病变称为“假肉瘤样筋膜炎”、“增生性筋膜炎”、“侵袭性筋膜炎”,或简称为“筋膜炎”,应用的最广泛的名称是“结节性筋膜炎”。 二、致病因素或病理机制 该病的主要病理机制是间质疏松水肿和黏液变,新生的毛细血管在病变周围呈放射状排列,红细胞外渗和炎症细胞浸润,部分病例浸润

Nodular fasciitis: characteristic imaging features on sonography and magnetic resonance imaging复制标题

结节性筋膜炎: 超声和磁共振成像的特征性成像特征

发表时间:2014-04-15

影响因子:1.7

作者: Khuu A

期刊:J Ultrasound Med

Nodular fasciitis, also known as infiltrative or pseudosarcomatous fasciitis, is a benign soft tissue tumor of fibroblastic/myofibroblastic differentiation that was first described in 1955 by Konwaler et al. The lesion often comes to clinical attention when a patient presents with a rapidly growing, occasionally painful, palpable soft tissue mass. Although benign and self-limited, nodular fasciitis is a clonal neoplastic proliferation characterized by recurrent MYH9-USP6 (myosin heavy chain 9–ubiquitin- specific peptidase 6) gene fusion. Despite the fact that in a large retrospective study nodular fasciitis was found to represent 11.3% of benign soft tissue tumors, relatively few descriptions of nodular fasciitis have appeared in the radiologic literature. Most of the reports have been published in oncologic, pathologic, and dermatologic literature. The imaging appearance has been described as nonspecific and mimicking other sarcomatous lesions. On sonography, occasional case reports have described the lesion as oval or lobulated and hypoechoic to muscle or of mixed echogenicity. On magnetic resonance imaging (MRI), nodular fasciitis has been described as inhomogeneous, hypointense to muscle on T1-weighted images, and hyperintense to fat on T2-weighted images, with variable enhancement.

译文

结节性筋膜炎,也称为浸润性或假肉瘤性筋膜炎,是一种成纤维细胞/肌成纤维细胞分化的良性软组织肿瘤,由Konwaler等人于1955年首次描述。当病人出现快速增长的,偶尔疼痛的,可触及的软组织肿块时,病变常常引起临床注意。结节性筋膜炎是一种良性、自限性的克隆性肿瘤增生,其特点是MYH9-USP6(肌球蛋白重链9-泛素特异性肽酶6)基因融合。尽管在一项大型回顾性研究中发现结节性筋膜炎占良性软组织肿瘤的11.3%,但在放射学文献中对结节性筋膜炎的描述相对较少。大多数报告发表在肿瘤学、病理学和皮肤病学文献中。影像学表现被描述为非特异性和模仿其他肉瘤病变。在超声检查中,偶有病例报告称病变为卵圆形或分叶状,对肌肉的低回声或混合回声。在磁共振成像(MRI)上,结节性筋膜炎在T1加权图像上表现为不均匀、对肌肉的低强度,在T2加权图像上表现为对脂肪的高强度,并伴有可变增强。