Vascular morphogenesis and remodeling in a model of tissue repair: blood vessel formation and growth in the ovarian pedicle after ovariectomy.
组织修复模型中的血管形态发生和重塑: 卵巢切除术后卵巢蒂的血管形成和生长。

摘要

To investigate mechanisms of vascular morphogenesis in tissue repair, we performed ovariectomy with resection of the corresponding branches of the ovarian vessels in nude mice. This induces a vascular network remodeling response in the healing ovarian pedicle. Reconstruction of 2000 histological serial sections demonstrated that a new vascular network composed of venous-venous loops forms in the wall of the dilated ovarian vein. Preexisting veins of all sizes, including a branch of the main artery, are subjected to segmentation. Loop formation and segmentation are based on intussusceptive microvascular growth. Loop formation is followed by elongation. Loop remodeling occurs also by intussusception and results in the formation of compound loop systems. All loop systems observed were completely patent. Blind-ending sprouts were extremely rare. Anastomoses between the preexisting vessels subjected to segmentation and the loop systems were established to include the newly formed vessels into the preexisting vascular network. The formation of an increasing number of patent loop systems likely decreases hypoxia and subsequently arrests angiogenesis with transformation of the granulation tissue into a scar. Loop formation also occurred inside a large thrombus that occluded a part of the lumen of the main vein.

译文

为了研究组织修复中血管形态发生的机制,我们在裸小鼠中进行了卵巢切除术,切除了相应的卵巢血管分支。这在愈合的卵巢蒂中诱导血管网络重塑反应。重建 2000年组织学连续切片表明,由静脉-静脉环组成的新血管网络在扩张的卵巢静脉管壁形成。预先存在的各种大小的静脉,包括主要动脉的一个分支,都会被分割。环路的形成和分割是基于肠套叠微血管的生长。环形成后是伸长。环路重塑也通过肠套叠发生,并导致复合环路系统的形成。观察到的所有回路系统都是完全专利的。盲端豆芽极其罕见。建立分割的原有血管和回路系统之间的吻合,将新形成的血管纳入原有血管网络。越来越多的专利环系统的形成可能会减少缺氧,并随后通过肉芽组织转化为疤痕来阻止血管生成。环的形成也发生在堵塞主静脉部分管腔的大血栓内部。

pedicle

骨科 脊柱手术 临床研究术语
概述  :  

椎弓根起于椎体后部,向后方突起,椎弓根外形呈弧形,并且与椎体、关节突和椎板融合在一起。   临床意义 近20年来,经椎弓根螺钉固定技术广泛用于腰椎管狭窄等脊柱外科手术中,不同文献报道的置钉误置率差别很大,这就要求外科医生对腰椎椎弓根的解剖有较为全面的认识,否则会出现严重手术相关并发症。   椎弓根螺钉与椎弓根 椎弓根螺钉置钉过深容易损伤腹腔血管等组织。有学者研究在30套成人干燥腰椎标本上测量了

pedicle 英 /'pedɪk(ə)l/  美 /'pɛdəkl/

释义   n. 蒂;[动] 肉茎;花梗;椎弓根

例句   In addition, pedicle screw constructs appear to have a better ability to correct scoliosis in comparison with hooks and hybrid constructs. 此外,与经钉钩固定和混合结构方式相比,椎弓根螺钉方式在纠正脊柱侧凸上有更好的优势。

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