首页 > 骨科医学词汇大全 > lumbar disc herniation
A functional polymorphism in COL11A1, which encodes the alpha 1 chain of type XI collagen, is associated with susceptibility to lumbar disc herniation.
COL11A1 中编码 XI 型胶原 α 1 链的功能多态性与椎间盘突出的易感性相关。

摘要

Lumbar disc herniation (LDH), degeneration and herniation of the nucleus pulposus of the intervertebral disc (IVD) of the lumbar spine, is one of the most common musculoskeletal diseases. Its etiology and pathogenesis, however, remain unclear. Type XI collagen is important for cartilage collagen formation and for organization of the extracellular matrix. We identified an association between one of the type XI collagen genes, COL11A1, and LDH in Japanese populations. COL11A1, which encodes the alpha 1 chain of type XI collagen, was highly expressed in IVD, but its expression was decreased in the IVD of patients with LDH. The expression level was inversely correlated with the severity of disc degeneration. A single-nucleotide polymorphism (c.4603C-->T [rs1676486]) had the most significant association with LDH (P=3.3 x 10(-6)), and the transcript containing the disease-associated allele was decreased because of its decreased stability. These observations indicate that type XI collagen is critical for IVD metabolism and that its decrease is related to LDH.

译文

腰间盘突出 (LDH),即腰椎椎间盘髓核 (IVD) 的变性和突出,是最常见的肌肉骨骼疾病之一。然而,其病因和发病机制仍不清楚。XI 型胶原对软骨胶原的形成和细胞外基质的组织很重要。我们确定了日本人群中 XI 型胶原基因 COL11A1 和乳酸脱氢酶之间的关联。COL11A1,编码 XI 型胶原的 α 1 链,在 IVD 中高表达,但在 IVD 中表达降低。表达水平与椎间盘退变的严重程度呈负相关。单核苷酸多态性 (c.4603C --> T [rs1676486]) 与乳酸脱氢酶的相关性最为显著 (P = 3.3x10 (-6),包含疾病相关等位基因的转录本因其稳定性降低而减少。这些观察表明,XI 型胶原对 IVD 代谢至关重要,其减少与乳酸脱氢酶有关。

lumbar disc herniation

骨科 腰椎间盘退行性变 疾病
概述  :  

腰椎间盘突出症是随着社会的发展,人们生活压力的增大,患病人数越来越多的一种疾病。当患有腰椎间盘突出症时,患者需要根据自己的实际情况和病情,选择相应的治疗手段,腰椎间盘突出的治疗方式和治疗手段比较多,为患者带来了很大的便利性。在日常生活中,由于人们经常在电脑前工作,缺乏有效锻炼,容易导致患腰椎间盘突出症。   预防方法 预防腰椎间盘突出,建议人们一定要多锻炼,多运动,不能久坐。注意休息,不能经常熬夜,可以多和朋友们进行一定的户外聚会,

Lumbar 英 /ˈlʌmbə(r)/   美 /ˈlʌmbər/ 

释义   adj. 腰的;腰部的

n. 腰椎;腰神经;腰动脉

例句   With acute lumbar disc herniation, studies have found that two and five years later, there's little difference between patients who had surgery and those who did not. 研究发现,两年和五年后,那些进行手术治疗和未进行手术的急性腰椎间盘突出患者之间无明显差异。

 

disc 英 /dɪsk/  美 /dɪsk/            

释义   n. 圆盘,[电子] 唱片(等于disk)

vt. 灌唱片

例句   They found a small object in the disc which may be the cause of the gap.  他们在圆盘上发现了一个小的杂质,可能是造成这个裂口的原因。

 

herniation /,hɝnɪ'eʃən/                     

释义   n. 形成疝

例句   Thus, annular disruption with a discrete leakage of nucleus pulposus material in the spinal canal, with no visible herniation, could be sufficient to induce symptoms of sciatica. 因此,在椎管内,纤维环的破裂与少量髓核组织的突出,不会见到明显的突出,但足以诱发坐骨神经痛的症状。


请扫描右侧二维码,免费查看词汇专业知识背景