Bone metastases of lung cancer Docetaxel Hyaluronic acid Osteoclasts PAMAM
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摘要

Bone is one of the prone metastatic sites of lung cancer. Osteoclast plays an important role in bone resorption and the growth of bone metastases of lung cancer. In order to treat bone metastases of lung cancer, we reported a docetaxel (DTX)-loaded nanoparticle, DTX@AHP, which could target dually at osteoclasts and bone metastatic tumor cells. The in vitro drug release from DTX@AHP exhibited pH and redox responsive characteristics. DTX@AHP displayed high binding affinity with bone matrix. In addition, DTX@AHP significantly inhibited the differentiation of RAW264.7 into osteoclast and effectively inhibited the proliferation of osteoclasts and tumor cells in in-vitro 3D bone metastases model of lung cancer. DTX@AHP could accumulate in bone metastases sites in vivo. Consequently, DTX@AHP not only markedly inhibited the growth of bone metastases of lung cancer but also reduced osteolysis in tumor-bearing mice. DTX@AHP exhibited great potential in the treatment of bone metastases of lung cancer.

译文

Bone is one of the prone metastatic sites of lung cancer. Osteoclast plays an important role in bone resorption and the growth of bone metastases of lung cancer. In order to treat bone metastases of lung cancer, we reported a docetaxel (DTX)-loaded nanoparticle, DTX@AHP, which could target dually at osteoclasts and bone metastatic tumor cells. The in vitro drug release from DTX@AHP exhibited pH and redox responsive characteristics. DTX@AHP displayed high binding affinity with bone matrix. In addition, DTX@AHP significantly inhibited the differentiation of RAW264.7 into osteoclast and effectively inhibited the proliferation of osteoclasts and tumor cells in in-vitro 3D bone metastases model of lung cancer. DTX@AHP could accumulate in bone metastases sites in vivo. Consequently, DTX@AHP not only markedly inhibited the growth of bone metastases of lung cancer but also reduced osteolysis in tumor-bearing mice. DTX@AHP exhibited great potential in the treatment of bone metastases of lung cancer.

Bone metastases

骨科 骨转移瘤 疾病
概述  :  

临床上骨骼往往是恶性肿瘤较为常见的转移部位,而转移性骨肿瘤会引起病理性骨折、疼痛、脊髓压迫等一系列的骨骼病变,对患者的生活质量产生影响,并威胁其生命安全。治疗转移性骨肿瘤的关键在于控制原发灶,并缓解疼痛。 流行病学大多数的恶性肿瘤晚期患者都会出现骨转移,主要以前列腺癌、乳腺癌及肺癌为主。超过70%的晚期前列腺癌,超过55%的晚期乳腺癌、肺癌都会发生骨转移,其他常见的还有大肠癌、肾癌、胃癌、女性生殖系统癌症等。肿瘤细胞转移的部位往往发生于脊柱,其次为骨盆和下肢长骨,膝、肘关节等较为少见。&nb

Bone 英 /bəʊn/  美 /boʊn/         

释    义   n. 骨;骨骼

vt. 剔去...的骨;施骨肥于

vi. 苦学;专心致志

n. (Bone)人名;(英)博恩;(法、西、罗、塞)博内;(老)奔

复数 bones过去式 boned过去分词 boned现在分词 boning第三人称单数 bones

同根词   bony adj.骨的;多骨的;瘦骨嶙峋的;似骨的;boned adj.骨骼的;去掉骨头的;用骨架撑起的;施过骨粉料的;去骨的;boneless adj.无骨的;boney n.瘦骨嶙峋的;多骨的

 

Boniness 英 /'bəʊnɪnɪs/

释    义   n. 多骨;憔悴;骨瘦如柴

例    句   They have to deduce from the shape of each bone what the muscles were like.他们必须从每块骨头的形状推断出肌肉的形状。

 

Metastases /mə'tæstəsɪs/

释    义   n. 转移(metastasis的复数) 

例    句   Thus, invasion and metastases are the most reliable indicators.因此,浸润和转移才是最可靠的指标。


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