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Osteochondroma

骨科

关键词骨科 疾病 良性骨肿瘤

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解析

Osteochondroma /,ɔstiəkɔn'drəumə/  

释义   n. [肿瘤] 骨软骨瘤

例句   Osteochondroma is a rare primary benign bone tumor that can occur in the sacrum. 骨软骨瘤是一种罕见的原发良性骨肿瘤,常发生在骶骨。


概述

骨软骨瘤是一种常见良性骨肿瘤,最好发部位为股骨下端和胫骨上端等四肢长管状骨,指骨等短管状骨少见。 临床表现患者多为无意中发现局部有一肿物,无疼痛及其他不适感,初期多未予重视及治疗。多数情况出现肿物缓慢生长,就诊近期出现较快增长,为进一步治疗至门诊检查。临床查体:四肢活动自如,肌力多为5级,病变区域肿胀,局部可触及肿物,质硬,活动性尚可,与皮肤无粘连,表皮无红肿,无静脉曲张。 诊断方法   众所周知,X 线检查跟CT 检查两者的基本成像原理是一致的,但是

MicroRNA profiling of multiple osteochondromas: identification of disease-specific and normal cartilage signatures复制标题

多发性骨软骨瘤的MicroRNA分析: 疾病特异性和正常软骨特征的鉴定

发表时间:2010-10-22

影响因子:4.1

作者: Zuntini M

期刊:Clin Genet

Multiple osteochondroma [MO (MIM #133700, #133701)] is an autosomal dominant disease characterized by multiple projections of bone (osteochondromas). Even if considered a rare disease, MO represents one of the most common skeletal disorders. Osteochondromas arise at the external surface of bones formed by endochondral ossification, and consist of a cartilage cap covering a bony stalk which is continuous with the underlying bone; chondrocytes located in the cartilage cap have the same spatial organization as those in the metaphyseal growth plate and also undergo endochondral ossification. Osteochondromas are rarely present at birth and grow in number and size during childhood, until skeletal maturity of patient with the closure of growth plate. The most serious complication of this pathology is malignant transformation into peripheral chondrosarcoma, which is estimated to occur in 1–5% of patients.

译文

多发性骨软骨瘤[MO(MIM#133700,#133701)]是一种常染色体显性遗传疾病,其特征在于骨骼的多个突起(骨软骨瘤)。 即使被认为是罕见疾病,MO仍是最常见的骨骼疾病之一。 骨软骨瘤出现在由软骨内骨化形成的骨骼的外表面,由覆盖骨茎的软骨帽组成,该软骨帽与下层骨连续。 软骨帽中的软骨细胞与干phy端生长板中的软骨细胞具有相同的空间组织,并且还会经历软骨内骨化。 骨软骨瘤很少在出生时出现,并且在儿童时期数量和大小会增长,直到患者的骨骼成熟并关闭生长板。 这种病理学最严重的并发症是恶性转变为周围软骨肉瘤,据估计,这发生在1-5%的患者中。