骨科
词汇介绍
拓展阅读
解析
Osteochondroma /,ɔstiəkɔn'drəumə/
释义 n. [肿瘤] 骨软骨瘤
例句 Osteochondroma is a rare primary benign bone tumor that can occur in the sacrum. 骨软骨瘤是一种罕见的原发良性骨肿瘤,常发生在骶骨。
概述
多发性骨软骨瘤的MicroRNA分析: 疾病特异性和正常软骨特征的鉴定
发表时间:2010-10-22
影响因子:4.1
作者: Zuntini M
期刊:Clin Genet
Multiple osteochondroma [MO (MIM #133700, #133701)] is an autosomal dominant disease characterized by multiple projections of bone (osteochondromas). Even if considered a rare disease, MO represents one of the most common skeletal disorders. Osteochondromas arise at the external surface of bones formed by endochondral ossification, and consist of a cartilage cap covering a bony stalk which is continuous with the underlying bone; chondrocytes located in the cartilage cap have the same spatial organization as those in the metaphyseal growth plate and also undergo endochondral ossification. Osteochondromas are rarely present at birth and grow in number and size during childhood, until skeletal maturity of patient with the closure of growth plate. The most serious complication of this pathology is malignant transformation into peripheral chondrosarcoma, which is estimated to occur in 1–5% of patients.
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