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Better efficacy of methotrexate given by intramuscular injection than orally in patients with rheumatoid arthritis.
在类风湿关节炎患者中,肌注甲氨蝶呤的疗效优于口服。

摘要

OBJECTIVE:To compare the clinical efficacy of methotrexate and tolerance to the drug in patients with rheumatoid arthritis who were switched from intramuscular to oral administration because of a shortage of the intramuscular preparation.
METHODS:143 patients were switched from intramuscular to oral methotrexate. Of these, 47 were switched back to the intramuscular form. A multiple choice questionnaire was sent by mail to evaluate clinical and biological criteria of efficacy and tolerance.
RESULTS:When methotrexate was first switched from intramuscular to oral administration, increased disease activity, exacerbation of morning pain and hand stiffness, duration of morning stiffness, increased joint pain, and increased joint swelling were observed. There was a greater frequency of gastrointestinal symptoms, but without a significant increase in liver abnormalities. When intramuscular methotrexate became available again, 47 of the 143 patients were switched back and were followed for at least three months. On average, disease manifestations were improved and side effects reduced by the switch.
CONCLUSIONS:Methotrexate given intramuscularly had improved clinical efficacy with fewer side effects than given orally. Intramuscular methotrexate administration should be considered when rheumatoid arthritis remains active in spite of high dose oral methotrexate.

译文

目的: 比较因肌肉注射制剂不足而从肌肉注射转为口服给药的类风湿关节炎患者对甲氨蝶呤的临床疗效和药物耐受性。
方法: 143 例患者从肌肉注射转为口服甲氨蝶呤。其中,47 人被转换回肌肉注射形式。通过邮件发送多项选择问卷,以评估疗效和耐受性的临床和生物学标准。
结果: 当甲氨蝶呤第一次从肌肉注射转为口服时,疾病活动增加,晨痛和手部僵硬加剧,晨僵持续时间延长,关节疼痛增加, 并观察到关节肿胀增加。胃肠道症状出现的频率更高,但肝脏异常没有显著增加。当肌注甲氨蝶呤再次可用时,143 名患者中的 47 名被调回,并接受至少三个月的随访。平均而言,疾病表现通过转换得到改善,副作用减少。
结论: 肌注甲氨蝶呤比口服甲氨蝶呤提高了临床疗效,副作用更少。当类风湿关节炎在大剂量口服甲氨蝶呤的情况下仍然活跃时,应考虑肌肉注射甲氨蝶呤。

intramuscular injection

骨科 药物注射方法 临床研究术语
概述  :  

肌肉注射是一种常用的药物注射治疗方法,指将药液通过注射器注入肌肉组织内,达到治病的目的。人在诸多的情况下都会需要进行肌肉注射药物,用这样的方法来治疗疾病。但是需要注意的是肌肉注射有诸多注意事项,尤其是在进行臀部肌肉注射的时候,有很多需引起重视的地方。  基本要求熟练掌握肌肉注射法目的、注射部位的定位方法;正确进行肌肉注射部位的定位,正确实施肌肉注射法,能够运用无痛注射技术;严格遵守无菌技术操作原则、注射原则,有严谨的工作态度。 操作方法1、携用物至床旁,进行三查七对,向病

intramuscular 英 /ˌɪntrəˈmʌskjələ(r)/  美 /ˌɪntrəˈmʌskjələr/         

释义   adj. 肌肉的;肌肉内的

例句   Is the move factor that inject uses intramuscular injection or hypodermic? 注射用的转移因子是肌肉注射还是皮下注射?

 

injection 英 /ɪnˈdʒekʃn/  美 /ɪnˈdʒekʃn/         

释义   n. 注射;注射剂;充血;射入轨道 

例句   Can you tell me this drug should be administered by intravenous injection or dripping? 你可以告诉我这个药是经由静脉注射还是静脉滴注吗?


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