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首页 > 医学词汇大全 > Meningitis
Meningitis

神经

关键词神经 疾病 弥漫性炎症

词汇介绍

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解析

purulent   英 [ˈpjʊərələnt]  美 [ˈpjʊrələnt] 

释    义   adj. 脓的;化脓的

同根词   purulence n. 脓;化脓;含脓;流脓 

purulency n. 化脓;脓性

例    句   Afterwards sees small ulcer after hair infection, fetid is ivory purulent sex secretion. 继发感染后可见小溃疡,有恶臭的乳白色脓性分泌物。

 

meningitis    英 [ˌmenɪnˈdʒaɪtɪs]  美 [ˌmenɪnˈdʒaɪtɪs] 

释    义   n. 脑膜炎

同根词   meningeal adj. 脑膜的

meningism n. 假性脑膜炎

例    句   What are the symptoms of bacterial meningitis? 细菌性脑膜炎的症状是什么?

概述

脑膜炎指软脑膜的弥漫性炎症性改变。由细菌、病毒、真菌、螺旋体、原虫、立克次体、肿瘤与白血病等各种生物性致病因子侵犯软脑膜和脊髓膜引起。小儿,尤其是婴幼儿常发化脓性脑膜炎。其中脑膜炎双球菌引起者最多见,可以发生流行,临床表现有其特殊性,称流行性脑脊髓膜炎。病因病原菌:2/3以上患儿由脑膜炎双球菌、流感嗜血杆菌及肺炎球菌引起。新生儿和小于2个月婴儿的常见致病菌为:革兰阴性细菌(大肠杆菌、绿脓杆菌)、金黄色葡萄球菌、B组溶血性链球菌。2个月婴儿-12岁儿童以流感嗜血杆菌、肺炎链球菌、脑膜炎双球菌为

Disease-specific molecular events in cortical multiple sclerosis lesions复制标题

皮质多发性硬化病变的疾病特异性分子事件

发表时间:2013-06-01

影响因子:11.8

作者: Marie Therese Fischer

期刊:Brain

Cortical lesions constitute an important part of multiple sclerosis pathology. Although inflammation appears to play a role in their formation, the mechanisms leading to demyelination and neurodegeneration are poorly understood. We aimed to identify some of these mechanisms by combining gene expression studies with neuropathological analysis. In our study, we showed that the combination of inflammation, plaque-like primary demyelination and neurodegeneration in the cortex is specific for multiple sclerosis and is not seen in other chronic inflammatory diseases mediated by CD8-positive T cells (Rasmussen's encephalitis), B cells (B cell lymphoma) or complex chronic inflammation (tuberculous meningitis, luetic meningitis or chronic purulent meningitis). In addition, we performed genome-wide microarray analysis comparing micro-dissected active cortical multiple sclerosis lesions with those of tuberculous meningitis (inflammatory control), Alzheimer's disease (neurodegenerative control) and with cortices of age-matched controls. More than 80% of the identified multiple sclerosis-specific genes were related to T cell-mediated inflammation, microglia activation, oxidative injury, DNA damage and repair, remyelination and regenerative processes. Finally, we confirmed by immunohistochemistry that oxidative damage in cortical multiple sclerosis lesions is associated with oligodendrocyte and neuronal injury, the latter also affecting axons and dendrites. Our study provides new insights into the complex mechanisms of neurodegeneration and regeneration in the cortex of patients with multiple sclerosis.

译文

皮质病变是多发性硬化病理学的重要组成部分。尽管炎症似乎在其形成中起作用,但导致脱髓鞘和神经退行性变的机制尚不清楚。我们的目的是通过结合基因表达研究和神经病理学分析来确定其中一些机制。在我们的研究中,我们发现炎症、斑块样原发性脱髓鞘和皮质神经变性的结合是多发性硬化的特异性,在其他由CD8阳性T细胞介导的慢性炎症性疾病(拉斯穆森脑炎)中未见。B细胞(B细胞淋巴瘤)或复杂的慢性炎症(结核性脑膜炎、淋菌性脑膜炎或慢性化脓性脑膜炎)。此外,我们还进行了全基因组微阵列分析,比较了活动性皮质多发性硬化病变与结核性脑膜炎(炎症控制)、阿尔茨海默病(神经退行性控制)和年龄匹配对照的皮质。80%以上的多发性硬化特异性基因与t细胞介导的炎症、小胶质细胞活化、氧化损伤、dna损伤与修复、再髓鞘化和再生过程有关。最后,我们通过免疫组化证实皮质多发性硬化病变中的氧化损伤与少突胶质细胞和神经元损伤有关,后者也影响轴突和树突。我们的研究为多发性硬化患者皮层神经变性和再生的复杂机制提供了新的见解。