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Neurotensin

神经

关键词神经 临床研究术语 肽类激素

词汇介绍

拓展阅读

解析

neurotensin

释    义   n. [生化] 神经降压素

短    语   neurotensin receptor 神经降压素受体

neurotensin assay 神经降压素测定

例    句   Our findings suggest that curcumin may be useful for colon cancer treatment, as well as potentialcolon cancer suppression, in cells that respond to this gastrointestinal hormone, neurotensin. 我们的发现表明黄素可能对治疗结肠癌很有用,同时在对胃肠激素神经降压素起反应的细胞内对结肠癌有潜在的抑制作用。

概述

神经降压肽(NT)是广泛分布于胃肠道的肽类激素,具有广泛的生物学功能。现已确定NT是一种含13个氨基酸残基的单键多肽,其氨基端为一个环状的Gin,羧基端是游离的,也时其受体结合部位所在。NT的生物活性主要取决于C端。NT广泛分布与脑和胃肠道中,85%在肠道,是由肠道N细胞分泌的,少量由肠道肌间神经从的神经纤维产生。N细胞主要分布于末端回肠黏膜内,空肠次之,胃、十二指肠和结肠含量很少。N细胞有一突起伸向肠黏膜刷状缘,与肠腔相通。因此,N细胞属于肠道开放型内分泌细胞。分布中枢神经系统:NT在中枢

Future of Theranostics: An Outlook on Precision Oncology in Nuclear Medicine复制标题

核医学中精准肿瘤学的未来

发表时间:2019-09-04

影响因子:7.4

作者: Thomas Langbein

期刊:J Nucl Med

Molecular alterations in malignant disease result in the expression or upregulations of various targets that can be used for imaging and treatment with radiopharmaceuticals. This theranostic principle has acquired greater importance in personalized medicine in recent years, particularly in oncology, where advanced tumors can be treated effectively with low side effects. Since the pioneering use of I in differentiated thyroid cancer in the 1940s, remarkable achievements in nuclear medicine endoradiotherapy have been demonstrated, mainly in the treatment of neuroendocrine neoplasms by using Lu-labeled somatostatin analogs or in the treatment of advanced prostate cancer using prostate-specific membrane antigen-directed radionuclide therapy. Besides that, this review focuses on promising novel radiopharmaceuticals and describes their preclinical and clinical status. Radiolabeled antibodies, such as I-omburtamab directed against the B7-H3 protein on the surface of neuroblastoma cells; HuMab-5B1, a Zr/Lu-labeled antibody for the treatment of CA19-9-expressing malignancies; and Lu-lilotomab, a CD37 antibody for the treatment of B-cell lymphomas, are being highlighted. The neurotensin receptor ligand In/Lu-3B-227 has demonstrated high potential in imaging and therapy for several malignancies (e.g., pancreatic adenocarcinomas).

译文

恶性疾病的分子改变导致各种靶点的表达或上调,这些靶点可用于放射药物的成像和治疗。近年来,这一治疗原则在个体化医疗中获得了更大的重要性,特别是在肿瘤领域,在肿瘤领域,晚期肿瘤可以有效治疗,且副作用小。自20世纪40年代I在分化型甲状腺癌中的首次应用以来,在核医学内放射治疗方面取得了显著的成就,主要用于lu标记生长抑素类似物治疗神经内分泌肿瘤或前列腺特异性膜抗原导向放射性核素治疗晚期前列腺癌。除此之外,本文还对新型放射性药物进行了综述,并介绍了它们的临床前和临床状况。放射标记抗体,如针对神经母细胞瘤细胞表面B7-H3蛋白的I-omburtamab;用于治疗CA19-9表达恶性肿瘤的ZR/Lu标记抗体Humab-5B1;以及用于治疗B细胞淋巴瘤的CD37抗体Lu-Lilotomab正受到重视。lu-3b-227中的神经降压素受体配体在一些恶性肿瘤(如胰腺腺癌)的影像学和治疗中显示出很高的潜力。