神经
词汇介绍
拓展阅读
解析
neurotensin
释 义 n. [生化] 神经降压素
短 语 neurotensin receptor 神经降压素受体
neurotensin assay 神经降压素测定
例 句 Our findings suggest that curcumin may be useful for colon cancer treatment, as well as potentialcolon cancer suppression, in cells that respond to this gastrointestinal hormone, neurotensin. 我们的发现表明黄素可能对治疗结肠癌很有用，同时在对胃肠激素神经降压素起反应的细胞内对结肠癌有潜在的抑制作用。
概述
概述
神经降压肽（NT）是广泛分布于胃肠道的肽类激素，具有广泛的生物学功能。现已确定NT是一种含13个氨基酸残基的单键多肽，其氨基端为一个环状的Gin，羧基端是游离的，也时其受体结合部位所在。NT的生物活性主要取决于C端。NT广泛分布与脑和胃肠道中，85%在肠道，是由肠道N细胞分泌的，少量由肠道肌间神经从的神经纤维产生。N细胞主要分布于末端回肠黏膜内，空肠次之，胃、十二指肠和结肠含量很少。N细胞有一突起伸向肠黏膜刷状缘，与肠腔相通。因此，N细胞属于肠道开放型内分泌细胞。
分布
中枢神经系统：NT在中枢神经系统有广泛分布。丘脑下部浓度最高，中脑、髓质，海马次之，小脑中含量极低。NT的亚细胞分布在突触体，而且它的解剖学分布与其受体密度之间彼此平行。
胃肠道：在大鼠，NT在肠道的含量为其总量的95%。在人回肠粘膜含量最高，空肠较少，胃、十二指肠和结肠只有微量，胰腺和胆囊未发现。
NT定位于回肠粘膜内分散的内分泌细胞，即N细胞中，N-细胞也属于开放型细胞。
生理作用
NT可能具有垂体促激素的作用。脑池内给予NT，可造成大鼠和小鼠低体温。NT还具有降低血压，增加血管通透性，增加红细胞压积，促进胰高血糖素释放，抑制胰岛素释放，刺激胃肠道收缩，以及抑制胃酸分泌等作用。在肝脏，可加速糖元分解。
Future of Theranostics: An Outlook on Precision Oncology in Nuclear Medicine
复制标题
核医学中精准肿瘤学的未来
发表时间：2019-09-04
影响指数：7.4
作者： Thomas Langbein
期刊：J Nucl Med
Molecular alterations in malignant disease result in the expression or upregulations of various targets that can be used for imaging and treatment with radiopharmaceuticals. This theranostic principle has acquired greater importance in personalized medicine in recent years, particularly in oncology, where advanced tumors can be treated effectively with low side effects. Since the pioneering use of I in differentiated thyroid cancer in the 1940s, remarkable achievements in nuclear medicine endoradiotherapy have been demonstrated, mainly in the treatment of neuroendocrine neoplasms by using Lu-labeled somatostatin analogs or in the treatment of advanced prostate cancer using prostate-specific membrane antigen-directed radionuclide therapy. Besides that, this review focuses on promising novel radiopharmaceuticals and describes their preclinical and clinical status. Radiolabeled antibodies, such as I-omburtamab directed against the B7-H3 protein on the surface of neuroblastoma cells; HuMab-5B1, a Zr/Lu-labeled antibody for the treatment of CA19-9-expressing malignancies; and Lu-lilotomab, a CD37 antibody for the treatment of B-cell lymphomas, are being highlighted. The neurotensin receptor ligand In/Lu-3B-227 has demonstrated high potential in imaging and therapy for several malignancies (e.g., pancreatic adenocarcinomas).
译文
