摘要

Current treatment with nucleos(t)ide analogs (NUCs) safely controls the replication of hepatitis B virus (HBV) and improves prognosis in patients with HBV. However, the inability to completely clear HBV is problematic and novel therapies are desired. It has been believed that all NUCs have similar function to inhibit HBV reverse-transcriptase. However, our recent findings that only acyclic nucleoside phosphonates (ANPs; adefovir dipivoxil and tenofovir disoproxil fumarate) had an additional effect of inducing interferon (IFN)-λ3 in the gastrointestinal tract suggests that ANPs are not only distinct in their structures but also in their functions from nucleoside analogs (lamivudine and entecavir). Since enteric lipopolysaccharide (LPS) can cross the intestine and affect peripheral blood mononuclear cells (PBMCs), we hypothesized that orally administered ANPs could have further additional effects to modulate LPS-mediated cytokine profile in PBMCs. This study showed that pretreatment of PBMCs, from either healthy volunteers or patients with HBV, with ANPs inhibited LPS-mediated interleukin (IL)-10 production, which reciprocally induced IL-12p70 and tumor necrosis factor-α production in a dose-dependent manner. Furthermore, the combination of IFN-α and ANPs synergistically enhanced LPS-mediated IL-12p70 production in PBMCs.

译文

目前用核苷类似物(nucs)治疗乙型肝炎病毒(hbv)可安全地控制其复制,改善患者的预后。然而,无法完全清除乙肝病毒是有问题的,需要新的治疗方法。目前认为,所有nucs对hbv逆转录酶的抑制作用相似。然而,我们最近的研究结果表明,只有无环核苷二磷酸(如阿德福韦酯和替诺福韦酯)在胃肠道中有诱导干扰素(IFN)- 3的额外作用,这表明核苷不仅在结构上不同,而且在核苷类似物(拉米夫定和)中的功能也不同。恩替卡维尔)。由于肠脂多糖(LPS)可以跨肠道并影响外周血单个核细胞(PBMC),我们假设口服给药ANPs可以进一步调节LPS介导的细胞因子在PBMCs中的作用。这项研究表明,来自健康志愿者或HBV患者ANPs的PBMC的预处理抑制LPS介导的白细胞介素(IL)- 10的产生,其相互作用诱导IL-12P70和肿瘤坏死因子-α的产生以剂量依赖的方式。此外,ifn-α和anps联合应用可协同促进lps介导的il-12p70在pbmcs中的产生。

Interferon

神经 糖蛋白 治疗药物
概述  :  

在两种病毒同时感染同一种细胞时,可发生一种病毒抑制另一种病毒复制的现象,称为病毒的于扰现象。干扰现象即为于扰素引起。干扰素是由病毒或其他干扰素诱生剂诱使人或动物细胞产生的一类糖蛋白,它具有抗病毒、抗肿瘤及免疫调节等多方面的生物活性。适应证主要用于治疗晚期毛细胞白血病、肾癌、黑色素瘤、Kaposi肉瘤、慢性粒细胞性白血病和中低度恶性非霍奇金淋巴瘤,其他曾用于骨肉瘤、乳腺癌,多发性骨髓瘤、头颈部癌和膀胱癌等。对慢性乙型、丙型肝炎也有效。用法用量用于病毒性感染和恶性肿瘤的全身治疗:每日100万~6

interferon    英 [ˌɪntəˈfɪərɒn]  美 [ˌɪntərˈfɪrɑːn] 

释    义   n. [生化][药] 干扰素

短    语   Interferon IFN 干扰素 

gamma interferon 干扰素;伽玛干扰素

alpha interferon 干扰素

例    句   We still use interferon but not that much.  我们也应用干扰素,但不是很多。

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