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首页 > 医学词汇大全 > Intracranial Arterial Dolichoectasia
Intracranial Arterial Dolichoectasia

神经

关键词神经 疾病 扩张性脑动脉病

词汇介绍

拓展阅读

解析

intracranial   [,ɪntrə'krenɪəl] 

释    义   adj. 颅内的

例    句   It is the protection of intracranial skull and the brain. 它保护的是头颅和颅内的大脑。

 

arterial    英 [ɑːˈtɪəriəl]  美 [ɑːrˈtɪriəl] 

释    义   adj. [解剖] 动脉的;干线的;像动脉的

例    句   This will have ramifications, all back thru the arterial system right to the top.  这些都有后果,所有的一切都通过我的动脉系统到达顶部。

 

dolichoectasia

释    义   n. 延长扩张

例    句   Objective To investigate whether vertebrobasilar dolichoectasia has relation with dizziness. 目的研究基底动脉极度过长弯曲是否与头晕有关。

概述

颅内动脉延长扩张症(IADE)亦称扩张性脑动脉病,表现为至少一支颅内动脉在长度和直径上增大,受累的颅内动脉扩张延长,有时甚至会蜿蜒迂曲。高达12%的IADE患者有卒中史。目前,IADE治疗方法的选择取决于患者的临床表现和疾病的严重程度,具体方法包括控制血压、抗血栓治疗、血管内治疗以及开颅手术。临床特征IADE的临床表现包括脑梗死、颅内血肿、脑神经或脑干压迫、第三脑室阻塞引起的脑积水和蛛网膜下腔出血。预后疾病的严重程度、试验设计、动脉自然增长时间以及临床表现的差异导致各项研究报道的IADE患者

Pathophysiology, presentation, prognosis, and management of intracranial arterial dolichoectasia复制标题

颅内动脉扩张症的病理生理、表现、预后和处理

发表时间:2015-08-01

影响因子:28.8

作者: Fernando Pico

期刊:Lancet Neurol

Up to 12% of patients with stroke have intracranial arterial dolichoectasia (IADE) and the basilar artery is affected in 80% of these cases. Diagnostic criteria and prognosis studies of IADE are based on basilar artery diameter, which is a good quantitative marker for the severity of the disease. The pathophysiology is largely unknown, but IADE can be viewed as a common final pathway of arterial wall response or damage in the tunica media due to various mechanisms, such as matrix metalloproteinase dysfunction or muscle cell or elastic fibre injury. No randomised controlled trials have been undertaken in IADE and thus little high-level evidence is available on which to base treatment guidelines. IADE management depends on clinical presentation and disease severity, and includes blood pressure control, antithrombotic treatments, endovascular procedures, and surgery. Further studies are needed to better define IADE in the general population, to establish its prevalence and pathophysiology, to identify subgroups at risk of life-threatening complications, and to offer effective treatment options.

译文

高达12%的脑卒中患者有颅内动脉扩张症(iade),其中80%的患者基底动脉受到影响。iade的诊断标准和预后研究均以基底动脉直径为基础,基底动脉直径是判断iade严重程度的良好量化指标。其病理生理机制尚不清楚,但iade可被视为多种机制导致的动脉壁反应或损伤的最终途径,如基质金属蛋白酶功能障碍、肌肉细胞或弹性纤维损伤。在iade中没有进行随机对照试验,因此很少有高水平的证据可以作为治疗指南的基础。iade的治疗取决于临床表现和疾病的严重程度,包括血压控制、抗血栓治疗、血管内手术和外科手术。需要进一步的研究来更好地定义一般人群中的iade,确定其患病率和病理生理学,确定有生命危险的并发症的亚组,并提供有效的治疗选择。