摘要

Two studies found that stroke patients with intracranial arterial dolichoectasia (IADE) had lacunar infarction more often than the control subjects. The relation between IADE and other manifestations of small-vessel disease (multilacunar state, leukoaraiosis, and état criblé) was not investigated. The magnetic resonance images of 510 patients with brain infarction in the Etude du Profil Genetique de l'Infarctus Cerebral (GENIC) study were evaluated for the diagnosis of multilacunar infarction (>1 lacunar infarct), leukoaraiosis (assessed in periventricular and subcortical regions according to Scheltens and colleagues' scale, with severe leukoaraiosis defined as a score > 8), état criblé (using a semiquantitative score ranging from 0-8, with severe EC > 4), and IADE (using the consensus method). By comparison with stroke patients without IADE (n = 447), IADE(+) stroke patients (n = 63) had significantly more frequent multilacunar state (51 vs 33%), severe leukoaraiosis (34 vs 19%), and severe état criblé (32 vs 12%). After adjustment for potential confounding factors, the odds ratios (95% confidence interval) for the presence of IADE were 2.05 (1.08-3.87) for multilacunar state, 2.40 (1.11-5.20) for severe leukoaraiosis, and 3.60 (1.43-9.08) for severe état criblé. The factors significantly associated with état criblé were older age and a familial history of stroke. IADE in stroke patients was independently associated with parenchymal manifestations of small-vessel disease. These conditions may have in common underlying pathophysiological processes.

译文

两项研究发现,患有颅内动脉扩张症 (IADE) 的中风患者比对照组更容易发生腔隙性梗死。IADE 与小血管疾病的其他表现 (多腔隙状态、脑白质疏松和 é tat cribl é) 之间的关系没有被研究。对 510 名脑梗患者的磁共振图像进行了评估,以诊断多腔隙性梗死 (> 1 腔隙性梗死), 脑白质疏松症 (根据 Scheltens 和同事的量表在脑室周围和皮质下区域进行评估,严重脑白质疏松症定义为评分> 8),é tat cribl é (使用半定量评分范围为 0-8,严重 EC> 4),和 IADE (使用共识法)。通过与没有 IADE 的中风患者 (n = 447) 的比较,IADE () 中风患者 (n = 63) 有明显更频繁的多腔隙状态 (51 比 33%), 严重的脑白质疏松症 (34 vs 19%) 和严重的 é tat cribl é (32 vs 12%)。在对潜在混杂因素进行调整后,IADE 存在的比值比 (95% 置信区间) 为 2.05 (1.08-3.87),多腔隙状态为 2.40 (1.11-5.20) 对于严重的脑白质疏松症,3.60 (1.43-9.08) 对于严重的 é tat cribl é。与 é tat cribl é 显著相关的因素是年龄较大和有中风家族史。中风患者的 IADE 与小血管疾病的实质表现独立相关。这些情况可能有共同的潜在病理生理过程。

Intracranial Arterial Dolichoectasia

神经 扩张性脑动脉病 疾病
概述  :  

颅内动脉延长扩张症(IADE)亦称扩张性脑动脉病,表现为至少一支颅内动脉在长度和直径上增大,受累的颅内动脉扩张延长,有时甚至会蜿蜒迂曲。高达12%的IADE患者有卒中史。目前,IADE治疗方法的选择取决于患者的临床表现和疾病的严重程度,具体方法包括控制血压、抗血栓治疗、血管内治疗以及开颅手术。临床特征IADE的临床表现包括脑梗死、颅内血肿、脑神经或脑干压迫、第三脑室阻塞引起的脑积水和蛛网膜下腔出血。预后疾病的严重程度、试验设计、动脉自然增长时间以及临床表现的差异导致各项研究报道的IADE患者

intracranial   [,ɪntrə'krenɪəl] 

释    义   adj. 颅内的

例    句   It is the protection of intracranial skull and the brain. 它保护的是头颅和颅内的大脑。

 

arterial    英 [ɑːˈtɪəriəl]  美 [ɑːrˈtɪriəl] 

释    义   adj. [解剖] 动脉的;干线的;像动脉的

例    句   This will have ramifications, all back thru the arterial system right to the top.  这些都有后果,所有的一切都通过我的动脉系统到达顶部。

 

dolichoectasia

释    义   n. 延长扩张

例    句   Objective To investigate whether vertebrobasilar dolichoectasia has relation with dizziness. 目的研究基底动脉极度过长弯曲是否与头晕有关。

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