首页 > 神经医学词汇大全 > Sympathectomy
Depression of endothelial nitric oxide synthase but increased expression of endothelin-1 immunoreactivity in rat thoracic aortic endothelium associated with long-term, but not short-term, sympathectomy.
内皮型一氧化氮合酶的抑制,但与长期而不是短期交感神经切除术相关的大鼠胸主动脉内皮中 endothelin-1 免疫反应性的表达增加。

摘要

Recent pharmacological studies have shown that perivascular nerves can influence the development and function of vascular endothelial cells (ECs). However, morphological studies have not yet been carried out to investigate whether these functional changes are associated with changes in vasoactive substances in ECs. We used postembedding electron microscopy (EM) triple gold-labeling immunocytochemistry to study the effects of short-term sympathectomy (3 days after 6-hydroxydopamine [6-OHDA] treatment) and long-term sympathectomy (guanethidine and 8 days after 6-OHDA) on the distribution of vasoactive substances in ECs of the rat thoracic aorta. The post-embedding immunocytochemistry, which can detect levels of label in individual cells, showed that there was a significant decrease in endothelial NO synthase (NOS3)-labeled, serotonin (5-HT)-labeled, and substance P (SP)-labeled, but a significant increase in endothelin-1 (ET-1)-labeled, gold particles in ECs after long-term, but not after short-term (3-day), sympathectomy. In conclusion, our results show that long-term sympathectomy causes an increase in ET-1 and decrease in NOS3, 5-HT, and SP immunoreactivity in ECs of the thoracic aorta. Our data also indicate that postembedding EM triple gold-labeling immunocytochemistry is a valuable technique for quantitative studies of the content of vasoactive substances in ECs.

译文

最近的药理学研究表明,血管周围神经可以影响血管内皮细胞 (ECs) 的发育和功能。然而,尚未进行形态学研究来调查这些功能变化是否与 ECs 中血管活性物质的变化有关。我们使用包埋后电子显微镜 (EM) 三重金标记免疫细胞化学来研究短期交感神经切除术的效果 (6-羟基多巴胺 [6-OHDA] 治疗后 3 天) 和长期交感神经切除术 (6-ohda 后 8 天) 对大鼠胸主动脉 ECs 血管活性物质分布的影响。嵌入后的免疫细胞化学可以检测单个细胞的标记水平,显示内皮一氧化氮合酶 (NOS3) 标记、血清素 (5-HT) 标记、和物质 P (SP)-标记,但 endothelin-1 (ET-1)-标记的显著增加,金颗粒在 ECs 后长期,但不是短期(3 天),交感神经切除术。总之,我们的结果表明,长期交感神经切除术会导致胸主动脉 ECs 中 ET-1 的增加和 NOS3 、 5-HT 和 SP 免疫反应性的降低。我们的数据还表明,嵌入后 EM 三重金标记免疫细胞化学是定量研究 ECs 中血管活性物质含量的有价值的技术。

Sympathectomy

神经 交感神经功能紊乱 疾病
概述  :  

 交感神经切断术是指通过外科手术的方法切断或切除一定部位的交感神经,治疗某些疾病。 手术指征 创伤后肢体痛:交感神经创伤后肢体痛中的灼痛。幻肢痛等传入神经阻滞痛不适于此于术。一般创伤后肢体灼痛能够自行缦解。如果长期不缓解,方考虑手术沿疗。血管性病变:交感神经切除术对肢体血管痉挛性疾病效果较好。由于冷或者情感变化影响而导致的痉挛适于做交感神经切除术。由于血栓、脉管炎、胶原病引起的血管闭塞也适于手术。近年来对肢体近端大血管闭塞进行直接手术,如搭桥术和血管内膜剥脱术,

sympathectomy [,sɪmpə'θektəmɪ]   [,sɪmpə'θɛktəmi] 

       n. 交感神经切除术

       Objective : To investigate the change of enzyme and twitch muscle fiber in spasmodic muscle after sympathectomy. 目的:探讨交感神经切断后,痉挛肌肉内酶与肌纤维结构的改变。

请扫描右侧二维码,免费查看词汇专业知识背景