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Ultrasonication-assisted synthesis of sphere-like strontium cerate nanoparticles (SrCeO3 NPs) for the selective electrochemical detection of calcium channel antagonists nifedipine.
超声辅助合成球形铈酸锶纳米颗粒 (SrCeO3 NPs),用于钙通道拮抗剂硝苯地平的选择性电化学检测。
Calcium channel antagonists Nanoparticles Nifedipine Sonochemical synthesis Strontium cerate
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摘要

In this work, strontium cerate nanoparticles (SrCeO3 NPs, SC NPs) were developed through facile synthetic techniques (Ultrasound-Assisted (UA) and Stirring-Assisted (SA) synthesis) and utilized as an electrocatalyst for the selective and sensitive electrochemical detection of calcium channel blocker nifedipine (NDF). The as-prepared UASC NPs and SASC NPs were characterized using XRD, Raman, TEM, EDS, mapping, XPS and BET analysis which exposed the formation of SC NPs in the form of spherical in shape and well crystalline in nature. BET studies reveal that UASC NPs have maximum surface area than that of SASC NPs. Further, the use of the as-developed UASC NPs and SASC NPs as an electrocatalyst for the detection of NDF. Interestingly, the UASC NPs modified screen printed carbon electrode (UASC NPs/SPCE) exhibited an excellent electrocatalytic activity in terms of lower reduction potential and enhanced reduction peak current when compared to SASC NPs and unmodified SPCE. Moreover, as-prepared UASC NPs/SPCE displayed wide linear response range (LR, 0.02-174 µM), lower detection limit (LOD, 5 nM) and good sensitivity (1.31 µA µM-1 cm-2) than that of SASC NPs (LR = 0.02-157 µM, LOD = 6.4 nM, sensitivity - 1.27 µA µM-1cm-2). Furthermore, UASC NPs/SPCE showed an excellent selectivity even in the existence of potentially co-interfering compounds such as similar functional group containing drugs, pollutants, biological substances and some common cations/anions. The developed sensor was successfully employed for the determination of NDF in real lake water, commercial NDF tablet and urine samples with acceptable recovery.

译文

在这项工作中,铈酸锶纳米粒子 (SrCeO3 NPs,SC NPs) 通过简单的合成技术 (超声波辅助 (UA) 和搅拌辅助 (SA) 合成) 被开发出来并作为电催化剂用于钙通道阻滞剂硝苯地平 (NDF) 的选择性和灵敏的电化学检测。用 XRD 、 Raman 、 TEM 、 EDS 、 mapping 、 XPS 和 BET 分析揭示了 SC NPs 的形成,其形状为球形,性质为结晶。BET 研究表明 UASC NPs 比 SASC NPs 有最大的表面积。此外,使用开发的 UASC NPs 和 SASC NPs 作为 NDF 检测的电催化剂。有趣的是,UASC NPs 修饰的丝网印刷碳电极 (UASC NPs/SPCE) 与 SASC NPs 和未改性的 SPCE 相比,在较低的还原电位和增强的还原峰电流方面表现出优异的电催化活性。此外,制备的 UASC NPs/SPCE 显示较宽的线性响应范围 (LR,0.02-μ m),较低的检测限 (LOD,5 μ nm) 和比 SASC NPs (LR  =-0) 好的灵敏度 (1.31 μ a μ m-1 μ cm-2)。 02-157 μ m,lod =-6。 4 纳米,灵敏度-1.27 μ a μ m-1cm-2)。此外,UASC NPs/SPCE 甚至在潜在的共干扰化合物如含有药物、污染物、生物物质和一些常见阳离子/阴离子的类似官能团的存在中也表现出了极好的选择性。所开发的传感器被成功地用于测定真实湖水、商业 NDF 片剂和回收率可接受的尿液样品中的 NDF。

Calcium Channel Antagonists

神经 阻滞剂 治疗药物
概述  :  

 钙通道拮抗剂,也叫钙通道阻滞剂,主要通过阻断心肌和血管平滑肌细胞膜上的钙离子通道,抑制细胞外钙离子内流,使细胞内钙离子水平降低而引起心血管等组织器官功能改变的药物。 作用部位和机制 ①通过细胞膜钙离子通道的钙离子流入。②抑制或减少了对钙离子敏感蛋白与钙离子的连接。这些敏感蛋白即就是心肌中原肌球蛋白,以及血管平滑肌中的钙调节物。⑧抑制或减少了钙离子在其储存部位,诸如肌浆网的钙离子触发的钙释放。④减少钙离子蛋白复合物的调节作用。 临床应用 冠心

calcium ['kælsɪəm]   ['kælsɪəm] 

       n. [化学]

       In fact, they may do your body harm, since chocolate can take away what calcium you do have. 事实上,他们可能会做你的身体伤害,因为确实巧克力可以导致钙损失

 

channel['tʃænl] 

       n. (美)沙内乐(人名)

n. 海峡;通道;航道;(电视)频道,(广播)波段;(交流)途径

v. 引导,开导;输送,传送;形成河道

       What channel do you like to watch best? 你最喜欢看哪一个频道的节目?

 

antagonist [æn'tæg(ə)nɪst]   [æn'tæɡənɪst] 

       n. 敌手;[解剖] 对抗肌;[生化] 拮抗物;反协同试剂

       He wondered what his antagonist was doing . 他不知道他的敌手在做些什么。

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