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Polymyositis

神经

关键词神经 疾病 炎性肌病

词汇介绍

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解析

polymyositis    [,pɔli,maiə'saitis] 

释    义   n. [外科] 多肌炎

短    语   idiopathic polymyositis 特发性多发性肌炎

例    句   Analysing the data of the clinical manifestations, biochemical tests, electromyographes andmuscular biopsies, the authors proposed the diagnostic criteria of polymyositis anddermatomyositis. 从临床表现、生化检查、肌电图及肌肉活检等方面进行分析,提出多发性肌炎与皮肌炎的诊断条件。

概述

 多发性肌炎(PM)和皮肌炎(DM)是骨骼肌非化脓性炎性肌病。PM指皮肤无损害,如肌炎伴皮疹者称DM。其本病病因不明,属自身免疫性疾病。发病机理与病毒感染、免疫异常、遗传及肿瘤等因素有关。在肌细胞内业已发现微小RNA病毒样结构,用电子显微镜还发现在皮肤和肌肉血管壁与内皮细胞中,发现了类似副粘液病毒核壳体的管状包涵体。已经发现的细胞介导的免疫反应对肌肉起着重要作用。骨骼骨血管内有IgM、IgG、C3的沉积,特别在儿童型皮肌炎阳性率更高。恶性肿瘤与皮肌炎的相关现象提示肿瘤可以引起肌炎,

Immune checkpoint failures in inflammatory myopathies: An overview复制标题

炎症性肌病的免疫检查点失败: 概述

发表时间:2018-06-06

影响因子:7.7

作者: Sandrine Herbelet

期刊:Autoimmun Rev

Dermatomyositis (DM), polymyositis (PM), inclusion body myositis (IBM), immune mediated necrotizing myopathy (IMNM) and overlap myositis (OM) are classified as inflammatory myopathies (IM) with involvement of autoimmune features such as autoreactive lymphocytes and autoantibodies. Autoimmunity can be defined as a loss in self-tolerance and attack of autoantigens by the immune system. Self-tolerance is achieved by a group of immune mechanisms occurring in central and periphal lymphoid organs and tissues, called immune checkpoints, that work in synergy to protect the body from harmful immune reactions. Autoimmune disorders appear when immune checkpoints fail. In this review, the different immune checkpoint failures are discussed in DM, PM, IBM and IMNM. Exploring research contribution in each of these immune checkpoints might help to highlight research perspectives in the field and obtain a more complete picture of IM disease pathology.

译文

皮肌炎(DM),多发性肌炎(PM),包涵体肌炎(IBM),免疫介导的坏死性肌病(IMNM)和重叠肌炎(OM)被归类为炎症性肌病(IM),其涉及自身免疫特征,例如自身反应性淋巴细胞和自身抗体。 自身免疫可以定义为免疫系统的自身耐受性丧失和自身抗原的攻击。 通过在中枢和外周淋巴器官和组织中发生的一组免疫机制(称为免疫检查点)实现自身耐受,其协同作用以保护身体免受有害的免疫反应。 免疫检查点失败时会出现自身免疫性疾病。 在这篇综述中,DM,PM,IBM和IMNM讨论了不同的免疫检查点故障。 探索每个免疫检查点的研究贡献可能有助于突出该领域的研究视角,并获得更完整的IM疾病病理学图片。