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[18F]Florbetapir positron emission tomography: identification of muscle amyloid in inclusion body myositis and differentiation from polymyositis.
[18F] Florbetapir 正电子发射断层扫描: 包涵体肌炎中肌肉淀粉样蛋白的鉴定及与多发性肌炎的鉴别。
amyloid diagnostics inclusion body myositis polymyositis positron emission tomography
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摘要

OBJECTIVES:With the tools available currently, confirming the diagnosis of inclusion body myositis (IBM) can be difficult. Many patients are initially misdiagnosed with polymyositis (PM). In this observational study at a UK adult neuromuscular centre, we investigated whether amyloid positron emission tomography could differentiate between IBM and PM.
METHODS:Ten patients with IBM and six with PM underwent clinical review, [18F]florbetapir positron emission tomography and MRI of skeletal musculature. Differences in [18F]florbetapir standardised uptake value ratios in skeletal muscle regions of interest were evaluated. Relationships between [18F]florbetapir standardised uptake value ratios and measures of disease severity (clinical and by MRI of skeletal muscle) were assessed.
RESULTS:[18F]florbetapir standardised uptake value ratios were significantly higher in those with IBM compared with PM for all assessed regions (total-[18F]florbetapir standardised uptake value ratio 1.45 (1.28 to 2.05) vs 1.01 (0.80 to 1.22), p=0.005). For total-[18F]florbetapir standardised uptake value ratios≥1.28, sensitivity and specificity for IBM was 80% and 100%, respectively.
CONCLUSIONS:[18F]florbetapir amyloid positron emission tomography differentiates IBM from PM. Successful development could facilitate accurate diagnosis, inclusion in clinical trials and help avoid unnecessary exposure to potentially harmful treatments.

译文

目的: 利用目前可用的工具,确认包涵体肌炎 (IBM) 的诊断可能是困难的。许多患者最初被误诊为多发性肌炎 (PM)。在英国成人神经肌肉中心的这项观察性研究中,我们调查了淀粉样正电子发射断层扫描能否区分 IBM 和 PM。
方法: 10 名 IBM 患者和 6 名 PM 患者接受了临床审查,[18F] florbetapir 正电子发射断层扫描和骨骼肌肉组织 MRI。评价 [18F] florbetapir 标准化摄取值比率在感兴趣的骨骼肌区域中的差异。评估了 [18F] florbetapir 标准化摄取值比率和疾病严重程度测量 (临床和通过骨骼肌 MRI) 之间的关系。
结果: [18F] 在所有评估地区,与 PM 相比,IBM 公司的 florbetapir 标准化摄取值比率明显更高 (总计-[18F] florbetapir 标准化摄取值比率 1.45 (1.28 比 2.05) vs 1.01 (0.80 至 1.22),p = 0.005)。对于总-[18F] florbetapir 标准摄取值比率 ≥ 1.28,IBM 的敏感性和特异性分别为 80% 和 100%。
结论: [18F] florbetapir 淀粉样蛋白正电子发射断层扫描区分 IBM 和 PM。成功的开发可以促进准确的诊断,纳入临床试验,并有助于避免不必要的潜在有害治疗。

Polymyositis

神经 炎性肌病 疾病
概述  :  

 多发性肌炎(PM)和皮肌炎(DM)是骨骼肌非化脓性炎性肌病。PM指皮肤无损害,如肌炎伴皮疹者称DM。其本病病因不明,属自身免疫性疾病。发病机理与病毒感染、免疫异常、遗传及肿瘤等因素有关。在肌细胞内业已发现微小RNA病毒样结构,用电子显微镜还发现在皮肤和肌肉血管壁与内皮细胞中,发现了类似副粘液病毒核壳体的管状包涵体。已经发现的细胞介导的免疫反应对肌肉起着重要作用。骨骼骨血管内有IgM、IgG、C3的沉积,特别在儿童型皮肌炎阳性率更高。恶性肿瘤与皮肌炎的相关现象提示肿瘤可以引起肌炎,

polymyositis    [,pɔli,maiə'saitis] 

释    义   n. [外科] 多肌炎

短    语   idiopathic polymyositis 特发性多发性肌炎

例    句   Analysing the data of the clinical manifestations, biochemical tests, electromyographes andmuscular biopsies, the authors proposed the diagnostic criteria of polymyositis anddermatomyositis. 从临床表现、生化检查、肌电图及肌肉活检等方面进行分析,提出多发性肌炎与皮肌炎的诊断条件。

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