神经
词汇介绍
拓展阅读
解析
periodic 英 [,pɪərɪ'ɒdɪk] 美 [,pɪrɪ'ɑdɪk]
释 义 adj. 周期的;定期的
同根词 period adj. 某一时代的 periodical [数] 周期的;定期的
periodically adv. 定期地;周期性地;偶尔;间歇
period n. 周期,期间;时期;月经;课时
periodical n. 期刊;杂志 periodicity [数] 周期性;频率;定期性
例 句 The periodic movements of the universe are the same, up and down from age to age. 宇宙的周期运动是同样的,从一个时代到另一个时代往返不已。
paralysis 英 [pə'rælɪsɪs] 美 [pə'ræləsɪs]
释 义 n. 麻痹;无力;停顿
同根词 paralyzed adj. 瘫痪的;麻痹的
paralytic adj. 麻痹的;瘫痪的;中风的
paralytic n. 中风患者;麻痹患者
paralyzed v. 使麻痹;使无力;使失去勇气
paralyze vt. 使麻痹;使瘫痪
paralyse vt. 使……无力;使……麻痹;使……瘫痪
例 句 An emotional person, mind, and no paralysis. 一个有情感的人,心,不再麻痹。
概述
Spider toxin inhibits gating pore currents underlying periodic paralysis复制标题
蜘蛛毒素抑制周期性麻痹的门控孔电流
发表时间:2018-04-24
影响因子:9.6
作者: Roope Männikkö
期刊:P NATL ACAD SCI USA
Gating pore currents through the voltage-sensing domains (VSDs) of the skeletal muscle voltage-gated sodium channel Na1.4 underlie hypokalemic periodic paralysis (HypoPP) type 2. Gating modifier toxins target ion channels by modifying the function of the VSDs. We tested the hypothesis that these toxins could function as blockers of the pathogenic gating pore currents. We report that a crab spider toxin Hm-3 from can inhibit gating pore currents due to mutations affecting the second arginine residue in the S4 helix of VSD-I that we have found in patients with HypoPP and describe here. NMR studies show that Hm-3 partitions into micelles through a hydrophobic cluster formed by aromatic residues and reveal complex formation with VSD-I through electrostatic and hydrophobic interactions with the S3b helix and the S3-S4 extracellular loop. Our data identify VSD-I as a specific binding site for neurotoxins on sodium channels. Gating modifier toxins may constitute useful hits for the treatment of HypoPP.
译文