神经
词汇介绍
拓展阅读
解析
low 英 [ləʊ] 美 [lo]
释 义 n. 洛戴维(Sir David 英国漫画家)
adj. (low) 低的,浅的;卑贱的;粗俗的;消沉的
adv. (low) 低声地;谦卑地,低下地
n. (low) 低;低价;低点;牛叫声
v. (low) 牛叫
同根词 lowly adj. 卑贱的;地位低的;谦逊的
lowly adv. 谦逊地;位置低下地;低声地
lowliness n. 卑微;下贱
lowness n. 低下;卑贱;微弱
例 句 This one is really of rather low priority. 这实在是一个相当低的优先事项。
molecular 英 [məˈlekjələ(r)] 美 [mə'lɛkjələr]
释 义 adj. [化学] 分子的;由分子组成的
短 语 molecular weight [化]分子量
molecular biology [化]分子生物学
molecular structure [化]分子结构
high molecular 高分子的
molecular sieve [化]分子筛
例 句 And there is only one explanation for that at the molecular level, which is common ancestor. 而对此唯一的解释就是,在分子水平上,我们有着共同的祖先。
weight 英 [weɪt] 美 [wet]
释 义 n. 重量,重力;负担;砝码;重要性
vt. 加重量于,使变重
n. (Weight)人名;(英)韦特;(捷)魏格特
同根词 weighted adj. [数] 加权的;加重的;衡量过的
weighty adj. 重的;重大的;严肃的 weightless 失重的;无重量的
weightily adv. 重要地;沉重地
例 句 I like the weight of this piece of technology. 我喜欢这块拍子所用的技术达到的重量。
dextran 英 ['dekstræn] 美 ['dɛkstrən]
释 义 n. [有化] 右旋糖酐;葡萄聚糖
短 语 dextran sulfate 葡聚糖硫酸酯;硫酸葡聚糖
例 句 OBJECTIVE To prepare hypertonic sodium chloride dextran 70 injection and establish itsstandard for quality control. 目的制备高渗氯化钠右旋糖酐70注射液,建立其质量控制标准。
概述
The EBI2-oxysterol axis promotes the development of intestinal lymphoid structures and colitis复制标题
EBI2-oxysterol轴促进肠道淋巴结构和结肠炎的发展
发表时间:2019-05-10
影响因子:7.4
作者: Annika Wyss
期刊:Mucosal Immunol
The gene encoding for Epstein-Barr virus-induced G-protein-coupled receptor 2 (EBI2) is a risk gene for inflammatory bowel disease (IBD). Together with its oxysterol ligand 7α,25-dihydroxycholesterol, EBI2 mediates migration and differentiation of immune cells. However, the role of EBI2 in the colonic immune system remains insufficiently studied. We found increased mRNA expression of EBI2 and oxysterol-synthesizing enzymes (CH25H, CYP7B1) in the inflamed colon of patients with ulcerative colitis and mice with acute or chronic dextran sulfate sodium (DSS) colitis. Accordingly, we detected elevated levels of 25-hydroxylated oxysterols, including 7α,25-dihydroxycholesterol in mice with acute colonic inflammation. Knockout of EBI2 or CH25H did not affect severity of DSS colitis; however, inflammation was decreased in male EBI2 mice in the IL-10 colitis model. The colonic immune system comprises mucosal lymphoid structures, which accumulate upon chronic inflammation in IL-10-deficient mice and in chronic DSS colitis.
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