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Plasmapheresis

神经

关键词神经 技术手段 临床治疗

词汇介绍

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解析

plasmapheresis    [,plæzmə'fɛrɪsɪs] 

释    义   n. [临床] 血浆除去法;[临床] 血浆取出法(免疫学用语)

       plasmapheresis method 血浆置换术

plasmapheresis monitor 血浆除去监视器

filtration plasmapheresis 滤过血浆置换

例    句   Plasmapheresis is the removal, treatment, and return of (components of) blood plasma fromblood circulation. 血浆去除法是从血液循环中移出、处理并回归(成分)血浆的方法。

概述

 血浆置换是通过血液净化技术清除血浆中诸如白身抗体、免疫复合物、毒物等大分子物质,以治疗多种疾病的方法。 适应证 1. 风湿免疫性疾病、系统性红斑狼疮2.血液系统疾病:多发性骨髓瘤、白血病3.神经系统疾病:重症肌无力4.肾疾病:抗肾小球基底膜病5.自身免疫性皮肤疾病6.代谢性疾病7.器官移植前去抗体 原理 利用体外循环治疗将患者的血液经离心法或膜分离法分离血浆与细胞成分后,弃去含自身抗体、免疫复合物、高黏稠物质、与蛋白质结合的毒素等

New insights in cryoglobulinemic vasculitis复制标题

冷球蛋白血症性血管炎的新见解

发表时间:2019-08-02

影响因子:7.5

作者: Filipa Silva

期刊:J AUTOIMMUN

Cryoglobulins are antibodies that precipitate at low temperatures and dissolve after rewarming. Cryoglobulinemia refers to the presence of circulating cryoglobulins and generally leads to a systemic inflammatory syndrome characterized by fatigue, arthralgia, purpura, ulcers, neuropathy and/or glomerulonephritis. The disease mainly involves small to medium-sized blood vessels and causes vasculitis due to cryoglobulin-containing immune complexes. Cryoglobulinemia is classified into three types (I, II and III) on the basis of immunoglobulin composition. Predisposing conditions include lymphoproliferative, autoimmune diseases and hepatitis C virus infection. The diagnosis of cryoglobulinemic syndrome is predominantly based on the presence of clinical features and laboratorial demonstration of serum cryoglobulins. The treatment strategy depends on the cause of cryoglobulinemia. For patients with chronic HCV infection, antiviral therapy is indicated. Immunosuppressive or immunomodulatory therapy, including steroids, plasmapheresis and cytotoxic agents, is reserved for organ-threatening manifestations. In this review, we discuss the main clinical presentations, diagnostic approach and treatment options.

译文

冷球蛋白是在低温下沉淀并在复温后溶解的抗体。冷球蛋白血症是指循环冷球蛋白的存在,并且通常导致全身性炎症综合征,其特征在于疲劳,关节痛,紫癜,溃疡,神经病和/或肾小球肾炎。该疾病主要涉及中小型血管,并且由于含有冷球蛋白的免疫复合物而引起血管炎。基于免疫球蛋白组成,冷球蛋白血症分为三种类型(I,II和III)。易感病症包括淋巴组织增生,自身免疫疾病和丙型肝炎病毒感染。冷球蛋白综合征的诊断主要基于临床特征的存在和血清冷球蛋白的实验证明。治疗策略取决于冷球蛋白血症的原因。对于慢性HCV感染的患者,需要抗病毒治疗。免疫抑制或免疫调节治疗,包括类固醇,血浆去除术和细胞毒性剂,保留用于器官威胁表现。在这篇综述中,我们讨论了主要的临床表现,诊断方法和治疗方案。