微信扫码关注“小狗文献”

即刻体验更多权益

文献多,下载快,翻译准

首页 > 医学词汇大全 > Cerebrospinal Fluid
Cerebrospinal Fluid

神经

关键词神经 临床研究术语 疾病诊断依据

词汇介绍

拓展阅读

解析

cerebrospinal    英 [,serɪbrə(ʊ)'spaɪn(ə)l]  美 [,sɛrəbro'spaɪnl] 

         adj. [解剖] 脑脊髓的

         cerebrospinal pressure 脑脊液压

cerebrospinal fibers 脑脊髓纤维

cerebrospinal neurasthenia 脑脊髓性神经衰弱

        To investigate the methods of prevention and repair of cerebrospinal rhinorrhea by transsphenoidal microsurgical approach. 目的探讨经鼻蝶入路显微手术脑脊液鼻漏的预防和修补方法。


fluid   英 ['fluːɪd]  美 ['fluɪd] 

         adj. 流动的;流畅的;不固定的   n. 流体;液体

同根词     fluidity n. [流]流动性;流质;易变性

fluidness n.流动性;流质;不固定性,易变性

         Neither this fluid nor the shed skin cells have much odor by themselves, but the bacteria working on both substances is another matter. 这种液体和脱落的表皮细胞自己都没什么气味,但是细菌作用在这两个物质上就又是另外一回事了。

概述

概 述脑脊液是由脑室的脉络丛分泌的透明水样液体,含有少量蛋白,细胞数为1~5个/毫升,而电解质的含量则较多。它的比重低(1.004~1.007),它和血液的渗透压是平衡的,它的总量约为125毫升、压力是70~180毫米水柱。有少量的脑脊液来自脑室膜和邻近的神经胶质、软一蛛网膜的毛细血管床;一般认为95%的脑脊液来自侧脑室的脉络丛。从此产生的脑脊液,经室间孔进入第三脑室;再经中脑水管通入第四脑室;通过第四脑室正中孔流入小脑延髓池,再经外侧孔注入桥池;最后,流到脑和脊髓的周围。临床上为帮助诊断中枢神

Alzheimer’s disease pathology: pathways between central norepinephrine activity, memory, and neuropsychiatric symptoms复制标题

阿尔茨海默病病理学: 中枢去甲肾上腺素活性、记忆和神经精神症状之间的途径

发表时间:2019-04-29

影响因子:11.6

作者: Heidi I. L. Jacobs

期刊:Molecular Psychiatry

The locus coeruleus (LC) supplies norepinephrine to the brain, is one of the first sites of tau deposition in Alzheimer’s disease (AD) and modulates a variety of behaviors and cognitive functions. Transgenic mouse models showed that norepinephrine dysregulation after LC lesions exacerbates inflammatory responses, blood–brain barrier leakage (BBB), and cognitive deficits. Here, we investigated relationships between central norepinephrine metabolism, tau and beta-amyloid (Aβ), inflammation, BBB-dysfunction, neuropsychiatric problems, and memory in-vivo in a memory clinic population (total n = 111, 60 subjective cognitive decline, 36 mild cognitively impaired, and 19 AD dementia). Cerebrospinal fluid (CSF) and blood samples were collected and analyzed for 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG), CSF/plasma albumin ratio (Q-alb), Aβ, phosphorylated tau, and interleukins. The verbal word learning task and the neuropsychiatric inventory assessed memory functioning and neuropsychiatric symptoms. Structural equation models tested the relationships between all fluid markers, cognition and behavior, corrected for age, education, sex, and clinical dementia rating score. Our results showed that neuropsychiatric symptoms show strong links to both MHPG and p-tau, whereas memory deficits are linked to MHPG via a combination of p-tau and inflammation-driven amyloidosis (30–35% indirect effect contribution). These results suggest that the LC-norepinephrine may be pivotal to understand links between AD pathology and behavioral and cognitive deficits in AD.

译文

蓝斑(LC)向大脑提供去甲肾上腺素,是阿尔茨海默病(AD)中首批tau沉积的位点之一,并调节各种行为和认知功能。转基因小鼠模型显示LC病变后去甲肾上腺素失调加剧了炎症反应,血脑屏障渗漏(BBB)和认知缺陷。在这里,我们研究了中枢去甲肾上腺素代谢,tau和β-淀粉样蛋白(Aβ),炎症,BBB功能障碍,神经精神问题和记忆临床人群体内记忆之间的关系(总n = 111,60主观认知下降,36轻度认知障碍,19年AD痴呆)。收集脑脊液(CSF)和血液样品并分析3-甲氧基-4-羟基苯乙二醇(MHPG),CSF /血浆白蛋白比(Q-alb),Aβ,磷酸化tau和白细胞介素。口头单词学习任务和神经精神病学清单评估记忆功能和神经精神症状。结构方程模型测试了所有流体标记,认知和行为之间的关系,校正了年龄,教育,性别和临床痴呆评分。我们的结果显示神经精神症状显示出与MHPG和p-tau的强烈联系,而记忆缺陷通过p-tau和炎症驱动的淀粉样变性的组合与MHPG相关(30-35%间接效应贡献)。这些结果表明,LC-去甲肾上腺素可能是理解AD病理学与AD中行为和认知缺陷之间联系的关键。