神经
词汇介绍
拓展阅读
解析
同根词 polymeric adj.聚合的;聚合体的
polymer n. [高分子] 聚合物
polymerization n.聚合;[高分子]聚合作用
polymerize vi.聚合
polymerise vi.聚合
polymerize vt.使……聚合
polymerise vt.使聚合(等于polymerize)
例 句 The cells of GM chickens make this fake polymerase. 转基因鸡的细胞能产生这种假聚合酶。
chain 英 [tʃeɪn] 美 [tʃen]
n. 链;束缚;枷锁 vt. 束缚;囚禁;用铁练锁住
n. (Chain)人名;(英)钱恩;(西)查因;(法)谢安
同根词 chained adj. 链接的;装链的
chained v. 束缚(chain的过去分词);用链条系住
例 句 This versions of the bike show one way of attaching crack and chain. 这个版本的自行车展示一个附加的方式打击和链。
reaction 英 [rɪ'ækʃ(ə)n] 美 [rɪ'ækʃən]
n. 反应,感应;反动,复古;反作用
同根词 reactive adj.反应的;电抗的;反动的
reactionary adj. 反动的;反动主义的;反对改革的
reactionist adj. 反动的
reactor n. [化工] 反应器;[核] 反应堆;起反应的人
reactionary n. 反动分子;反动派
reactivity n. 反应;反动
reactant n. [化学] 反应物;反应剂 reactance [电] 电抗;感应抵抗
reactivation n. [物化] 再活化;再生;复能的情况;[核] 重激活
reactionism n. 极端保守主义;反动思想
reactionist n.反动分子;保守论者
react vi.反应;影响;反抗;起反作用
react vt. 使发生相互作用;使起化学反应
例 句 An Action and Reaction. 一个动作和反应。
概述
强迫症患者眶额皮质和纹状体兴奋性突触基因表达的初步研究
发表时间:2019-04-03
影响因子:11.6
作者: Sean C. Piantadosi
期刊:Molecular Psychiatry
Obsessive compulsive disorder (OCD) is a severe illness that affects 2–3% of people worldwide. OCD neuroimaging studies have consistently shown abnormal activity in brain regions involved in decision-making (orbitofrontal cortex [OFC]) and action selection (striatum). However, little is known regarding molecular changes that may contribute to abnormal function.We therefore examined expression of synaptic genes in post-mortem human brain samples of these regions from eight pairs of unaffected comparison and OCD subjects. Total grey matter tissue samples were obtained from medial OFC (BA11), lateral OFC (BA47), head of caudate, and nucleus accumbens (NAc). Quantitative polymerase chain reaction (qPCR) was then performed on a panel of transcripts encoding proteins related to excitatory synaptic structure, excitatory synaptic receptors/transporters, and GABA synapses. Relative to unaffected comparison subjects, OCD subjects had significantly lower levels of several transcripts related to excitatory signaling in both cortical and striatal regions. However, a majority of transcripts encoding excitatory synaptic proteins were lower in OFC but not significantly different in striatum of OCD subjects. Composite transcript level measures supported these findings by revealing that reductions in transcripts encoding excitatory synaptic structure proteins and excitatory synaptic receptors/transporters occurred primarily in OFC of OCD subjects. In contrast, transcripts associated with inhibitory synaptic neurotransmission showed minor differences between groups. The observed lower levels of multiple glutamatergic transcripts across both medial and lateral OFC may suggest an upstream causal event. Together, these data provide the first evidence of molecular abnormalities in brain regions consistently implicated in OCD human imaging studies.
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