微信扫码关注“小狗文献”

即刻体验更多权益

文献多,下载快,翻译准

首页 > 医学词汇大全 > Alzheimer’s disease
Alzheimer’s disease

神经

关键词神经 疾病 临床疾病

词汇介绍

拓展阅读

解析

Alzheimer   美 ['ælz'ɛmɚ] 

       n. 阿尔茨海默病(等于Alzheimer’s disease

       alzheimer disease 阿尔茨海默病;老年痴呆症

        No one knows how the radiation protects against Alzheimer's, but the team has some ideas. 还无人知晓辐射如何对抗老年痴呆症,但是实验组有了一些想法。

 

disease   英 [dɪ'ziːz]   [dɪ'ziz] 

          n. 病,[] 疾病;弊病

     vt. 传染;使有病

同根词      diseased adj. 不健全的;患病的;病态的 

diseaseful adj. 不健康的,产生细菌的

diseased v. 使生病;传染(disease的过去分词)

          If we die in that hour, the disease wins. 如果我们那时死了,那就是疾病的胜利。

概述

流行病学调查发现,阿尔茨海默病(AD)是痴呆最常见的原因。65岁以后,每增加5岁,AD的发病率就会增加1倍;85岁以上的老年人中,约50%患有AD。预计2050年以后,AD的患病率将是目前的4倍,将给患者家庭和整个社会造成越来越沉重的负担。人们一直以来都认为痴呆是年龄增长不可避免的结局。由于缺乏对痴呆早期诊断重要性的认识,并且认为治疗措施有限,所以AD患者通常都难以得到最佳的诊断和治疗。研究显示,只有不到50%的患者进行过正规的诊断,而接受正规治疗的患者就更少。发病机制AD病因迄今不明,发病

Cytosolic Ca2+ Buffers Are Inherently Ca2+ Signal Modulators复制标题

胞浆Ca2 + 缓冲液本身就是Ca2 + 信号调节剂

发表时间:2019-06-15

影响因子:9.1

作者: Beat Schwaller

期刊:Cold Spring Harb Perspect Biol

For precisely regulating intracellular Ca signals in a time- and space-dependent manner, cells make use of various components of the "Ca signaling toolkit," including Ca entry and Ca extrusion systems. A class of cytosolic Ca-binding proteins termed Ca buffers serves as modulators of such, mostly short-lived Ca signals. Prototypical Ca buffers include parvalbumins (α and β isoforms), calbindin-D9k, calbindin-D28k, and calretinin. Although initially considered to function as pure Ca buffers, that is, as intracellular Ca signal modulators controlling the shape (amplitude, decay, spread) of Ca signals, evidence has accumulated that calbindin-D28k and calretinin have additional Ca sensor functions. These other functions are brought about by direct interactions with target proteins, thereby modulating their targets' function/activity. Dysregulation of Ca buffer expression is associated with several neurologic/neurodevelopmental disorders including autism spectrum disorder (ASD) and schizophrenia. In some cases, the presence of these proteins is presumed to confer a neuroprotective effect, as evidenced in animal models of Parkinson's or Alzheimer's disease.

译文

为了以时间和空间依赖的方式精确调节细胞内Ca信号,细胞利用“Ca信号传导工具包”的各种组分,包括Ca进入和Ca挤出系统。称为Ca缓冲液的一类胞质Ca结合蛋白用作这种大多数短寿命Ca信号的调节剂。原型Ca缓冲液包括parvalbumins(α和β同种型),calbindin-D9k,calbindin-D28k和calretinin。虽然最初被认为起到纯Ca缓冲剂的作用,即,作为控制Ca信号形状(振幅,衰减,扩散)的细胞内Ca信号调节剂,证据表明calbindin-D28k和calretinin具有额外的Ca传感器功能。这些其他功能是通过与靶蛋白的直接相互作用产生的,从而调节其靶标的功能/活性。 Ca缓冲液表达的失调与几种神经/神经发育障碍有关,包括自闭症谱系障碍(ASD)和精神分裂症。在某些情况下,假定这些蛋白质的存在赋予神经保护作用,如帕金森病或阿尔茨海默病的动物模型中所证明的。