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首页 > 医学词汇大全 > Migraine
Migraine

神经

关键词神经 疾病 临床疾病

词汇介绍

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解析

migraine    ['miːgreɪn; 'maɪ-]   ['maɪɡren] 

       n. [内科] 偏头痛

  n. (Migraine)人名;()米格雷纳

       Complicated migraine 复杂性偏头痛;复杂型偏头痛;性偏头痛

classic migraine 典型偏头痛;偏头痛;经典型偏头痛

Probable migraine 可能的偏头痛;很可能的偏头痛

        The cause of migraine have? How to do?  偏头痛的原因有哪些?怎么办?

概述

偏头痛是一类周期性反复发作的以单侧或双侧头痛为特征的疾病,常见于儿童期、青春期或成年早期发生,发作时可伴有恶心、呕吐、畏光、恐声和倦怠等症状。影响因素(1)遗传:其遗传形式的多样和外显率的不一,也可能是多个基因与环境因素相互作用而产生的综合征。某些有先兆的偏头痛和家族偏瘫型偏头痛具有明显的常染色体显性遗传,且外显率很高。(2)内分泌因素:女性患者倾向于月经前发作。约15%女性偏头痛患者仅在月经前后发生,据认为此种偏头痛与雌二醇撤退有关。应用避孕药可使头痛程度和频率增加,甚至导致永久性神经功能

Hsa-miR-34a-5p and hsa-miR-375 as Biomarkers for Monitoring the Effects of Drug Treatment for Migraine Pain in Children and Adolescents: A Pilot Study复制标题

Hsa-miR-34a-5p和hsa-miR-375作为监测儿童和青少年偏头痛药物治疗效果的生物标志物: 一项初步研究

发表时间:2019-06-27

影响因子:5.7

作者: Luca Gallelli

期刊:J Clin Med

A cornerstone in modern medicine is undoubtedly the discovery of the family of non-coding RNA, also known as microRNA (miR). These biomolecules suppress target mRNA translation and stability for a large segment of the transcriptome, and their influence on gene expression occurs within the cells producing them, as well as in remote cells through extracellular tracking. Moreover, miR mediate also epigenetic modification in chronic neuropathic pain and in migraine and represent a functional interplay between serum miRs levels and drugs exposure therefore they could play a role as biomarker candidate.Moreover, in a clinical study, Andersen and colleagues described an increased expression of has-miR-34a-5p in patients with migraine attacks, while Chen et al. reported that hsa-miR-375 plays pivotal roles in cancer, metabolic, immune disease and inflammatory diseases.Based on those observations, in this study we evaluated the expression of hsa-miR-34a-5p and hsa-miR-375 in serum and saliva of treated and untreated children with migraine without aura.

译文

现代医学的基石无疑是非编码RNA家族的发现,也称为microRNA(miR)。这些生物分子抑制大部分转录组的靶mRNA翻译和稳定性,并且它们对基因表达的影响发生在产生它们的细胞内,以及通过细胞外追踪的远程细胞中。此外,miR还介导慢性神经性疼痛和偏头痛中的表观遗传修饰,并代表血清miR水平和药物暴露之间的功能性相互作用,因此它们可以起到生物标志物候选者的作用。此外,在一项临床研究中,Andersen及其同事描述了患有偏头痛发作的患者中has-miR-34a-5p的表达增加,而Chen等人。据报道,hsa-miR-375在癌症,代谢,免疫疾病和炎症性疾病中发挥关键作用。基于这些观察,在本研究中,我们评估了hsa-miR-34a-5p和hsa-miR-375在治疗和未治疗的患有无先兆偏头痛的儿童的血清和唾液中的表达。