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Mannitol

神经

关键词神经 治疗药物 糖醇

词汇介绍

拓展阅读

解析

mannitol   英 ['mænɪtɒl]  美 ['mænɪtol]

释    义    n. [生化] 甘露醇,甘露糖醇

例    句    Mannitol is approximately 50 % as sweet as sucrose and non-cariogenic. 甘露醇的甜度约为蔗糖的50%,不引起龋齿。

概述

甘露醇是山梨糖醇的同分异构体,两种醇类物质的二号碳原子上羟基朝向不同,分子式是C6H14O6,分子量为182.17。易溶于水,为白色透明的固体,有类似蔗糖的甜味。 作用与用途 本品为单糖,在体内不被代谢,其高渗溶液静滴后,具有组织脱水和利尿作用。用于①各种原因所致的脑水肿,降低颅内压,防止脑疝。②降低眼内压,用于其他降眼内压药无效时或眼内手术前准备。③鉴别肾前性因素或肾性因素所致的少尿。亦可用于各种原因所致的急性肾小管坏死。④肾病

In vitro demonstration of intestinal absorption mechanisms of different sugars using 3D organotypic tissues in a fluidic device复制标题

在流体装置中使用3D器官型组织体外演示不同糖的肠道吸收机制

发表时间:2019-12-30

影响因子:6.2

作者: Alessandra Marrella

期刊:ALTEX

Intestinal permeability is crucial in regulating the bioavailability and consecutively the biological effects of drugs and compounds. However, systematic and quantitative studies of absorption of molecules are quite limited due to the lack of reliable experimental models able to mimic in vivo responses. In this work, we present a novel platform as in vitro fluidic model of healthy and pathological small intestinal barrier using 3D reconstructed intestinal epithelium integrated with a fluid-dynamic bioreactor resembling the physiological stimuli of the intestinal environment (MIVO®). The platform has been investigated, both in healthy and induced pathological conditions, by monitoring the absorption of two non-metabolized sugars, lactulose and mannitol, frequently used as indicators of intestinal barrier dysfunctions. The results showed that an in vivo-like plateau of the percentage of absorbed sugars was reached for lactulose and mannitol and that the mannitol absorbed was much greater than the lactulose, in line with clinical data, thus revealing the good reliability of the model.

译文

肠道通透性在调节药物和化合物的生物利用度和生物效应方面至关重要。然而,由于缺乏能够模拟体内反应的可靠实验模型,对分子吸收的系统和定量研究十分有限。在这项工作中,我们提出了一个新的平台,作为健康和病理性小肠屏障的体外流体模型,该平台使用三维重建的肠上皮,并结合类似于肠环境生理刺激的流体动力生物反应器(MIVO ®)。通过监测两种非代谢糖(乳果糖和甘露醇)的吸收,在健康和诱导的病理条件下对该平台进行了研究,这两种糖通常被用作肠屏障功能障碍的指标。结果表明,乳果糖和甘露醇的体内糖分吸收率达到了一个类似于高原的水平,甘露醇的吸收量远大于乳果糖,符合临床资料,表明该模型具有良好的可靠性。