mannitol 英 ['mænɪtɒl] 美 ['mænɪtol]
释 义 n. [生化] 甘露醇，甘露糖醇
例 句 Mannitol is approximately 50 % as sweet as sucrose and non-cariogenic. 甘露醇的甜度约为蔗糖的50%，不引起龋齿。
作者： Alessandra Marrella
Intestinal permeability is crucial in regulating the bioavailability and consecutively the biological effects of drugs and compounds. However, systematic and quantitative studies of absorption of molecules are quite limited due to the lack of reliable experimental models able to mimic in vivo responses. In this work, we present a novel platform as in vitro fluidic model of healthy and pathological small intestinal barrier using 3D reconstructed intestinal epithelium integrated with a fluid-dynamic bioreactor resembling the physiological stimuli of the intestinal environment (MIVO®). The platform has been investigated, both in healthy and induced pathological conditions, by monitoring the absorption of two non-metabolized sugars, lactulose and mannitol, frequently used as indicators of intestinal barrier dysfunctions. The results showed that an in vivo-like plateau of the percentage of absorbed sugars was reached for lactulose and mannitol and that the mannitol absorbed was much greater than the lactulose, in line with clinical data, thus revealing the good reliability of the model.