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首页 > 医学词汇大全 > Felbamate
Felbamate

神经

关键词神经 治疗药物 抑制剂

词汇介绍

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解析

felbamate

释义    非氨酯

例句    The intermediate reacted with methyl carbamate to obtain felbamate.该中间体与氨基甲酸甲酯反应制得非氨酯。

概述

非氨酯是一种弱的碳酸酐酶抑制剂,可增加苯妥英钠的血药浓度,有时需减少20%的苯妥英钠量,以维持原来的稳态浓度。其机制可能是非氨酯竞争性抑制苯妥英钠的代谢。非氨酯可使卡互西平浓度显著降低,清除率增加28%。非氨酯对丙戊酸的影响小。 作用机制 ①拮抗甘氨酸调节点上的NMDA受体; ②阻断电压依赖性钠通道,抑制兴奋性神经递质的释放: ③增加GABA能神经递质浓度。它对NMDA受体部位的抑制作用及对GABAA受体

Recurrent epileptiform discharges in the medial entorhinal cortex of kainate-treated rats are differentially sensitive to antiseizure drugs复制标题

红藻氨酸治疗大鼠内嗅皮质复发性癫痫样放电对抗癫痫药物的敏感性差异

发表时间:2018-11-15

影响因子:5.6

作者: Peter J West

期刊:Epilepsia

RESULTS: ASDs targeting sodium and potassium channels (carbamazepine, eslicarbazepine, ezogabine, lamotrigine, lacosamide, phenytoin, and rufinamide) attenuated REDs at concentrations near their average therapeutic plasma concentrations. γ-aminobutyric acid (GABA)ergic synaptic transmission-modulating ASDs (clobazam, midazolam, phenobarbital, stiripentol, tiagabine, and vigabatrin) attenuated REDs only at higher concentrations and, in some cases, prolonged RED durations. ASDs with other/mixed mechanisms of action (bumetanide, ethosuximide, felbamate, gabapentin, levetiracetam, topiramate, and valproate) and glutamate receptor antagonists weakly or incompletely inhibited RED frequency, increased RED duration, or had no significant effects.

译文

结果:以钠和钾通道为靶点的ASDs(卡马西平、沙利卡比平、依佐加滨、拉莫三嗪、拉科塞米、苯妥英钠和鲁非那胺)在接近其平均治疗血浆浓度时使红细胞减弱。γ-氨基丁酸(GABA)能调节ASDs(clobazam,咪达唑仑,苯巴比妥,stirethetol,tiagabine,vigabatin)仅在较高浓度下减弱红色,在某些情况下延长红色持续时间。具有其他/混合作用机制的ASDS(丁哌他胺、乙氧琥珀酸、非特氨酸、加巴喷丁、左乙拉西坦、托吡酯和丙戊酸)和谷氨酸受体拮抗剂弱或不完全抑制红频率,增加红色持续时间,或没有显著影响。