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首页 > 医学词汇大全 > Celecoxib
Celecoxib

神经

关键词神经 治疗药物 非甾体消炎药

词汇介绍

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解析

celecoxib

释义    n. 塞来昔布

例句    Celecoxib maybe inhibit the growth of bladder cancer via inducing apoptosis of tumor cells and perhaps will become a choice of chemoprevention and adjuvant therapy of bladder cancer.塞来昔布可能通过促进肿瘤细胞凋亡等途径对膀胱肿瘤产生抑制作用,可能成为膀胱肿瘤化学预防及治疗的辅助手段。

概述

本药为新一代非甾体消炎药,该药为口服硬胶囊。塞来昔布具有独特的作用机制即特异性地抑制环氧化酶-2,从而减少导致炎性前列腺素类物质的合成和聚积,尤其是前列腺素E2,进一步减轻组织炎症,水肿和疼痛。因此,塞来昔布可通过抑制环氧化酶-2阻止炎性前列腺素物质的产生,达到抗炎、镇痛及退热作用。 药理作用与药代动力学 塞来昔布为新一代非甾体类抗炎镇痛药,即选择性环氧化酶-2抑制剂,针对性抑制环氧化酶-2,抗炎镇痛同时大大降低了消化道不良反应。塞来昔布

Coadministration of lithium and celecoxib reverses manic-like behavior and decreases oxidative stress in a dopaminergic model of mania induced in rats复制标题

锂和塞来昔布共同给药可逆转大鼠躁狂样行为并降低多巴胺能性躁狂模型的氧化应激

发表时间:2019-11-13

影响因子:5.2

作者: Samira S Valvassori

期刊:Transl Psychiatry

The present study intends to investigate the effect of lithium (Li) and celecoxib (Cel) coadministration on the behavioral status and oxidative stress parameters in a rat model of mania induced by dextroamphetamine (d-AMPH). Male Wistar rats were treated with d-AMPH or saline (Sal) for 14 days; on the 8th day of treatment, rats received lithium (Li), celecoxib (Cel), Li plus Cel, or water until day 14. Levels of oxidative stress parameters were evaluated in the serum, frontal cortex, and hippocampus. d-AMPH administration induced hyperlocomotion in rats, which was significantly reversed by Li and Cel coadministration.

译文

本研究旨在探讨锂(李)和塞来昔布(CEL)联合用药对大鼠右苯丙胺诱导的躁狂症模型的行为状态和氧化应激参数的影响。雄性Wistar大鼠用D- AMPH或生理盐水(Sal)治疗14天;在治疗的第八天,大鼠接受锂(李)、塞来昔布(CEL)、李+ CEL或水,直到第14天。在血清、额叶皮质和海马中评估氧化应激参数的水平。d-amf诱导大鼠运动过度,Li和Cel联合给药可明显逆转。