methotrexate 英 [,meθə'trekseɪt; ,miːθə-] 美 [,mɛθə'trɛkset]
释义 n. 甲氨蝶呤，[药] 氨甲叶酸，[药] 氨甲蝶呤
例句 This is important, as people prescribed methotrexate are often advised to limit their alcohol intake to avoid possible liver problems. 这点很重要，因为根据规定，甲氨蝶呤服用过程中要限制酒精的摄入以避免可能引起的肝脏损伤。
作者： Agnieszka Bojko
It is acknowledged that cancer cells are able to undergo senescence in response to clinically used chemotherapeutics. Moreover, recent years have provided evidence that some drugs can selectively remove senescent cells. Therefore, it is essential to properly identify and characterize senescent cells, especially when it comes to cancer. Senescence was induced in various cancer cell lines (A549, SH-SY-5Y, HCT116, MDA-MB-231, and MCF-7) following treatment with doxorubicin, irinotecan, methotrexate, 5-fluorouracil, oxaliplatin, or paclitaxel. Treatment with tested chemotherapeutics resulted in upregulation of p21 and proliferation arrest without cytotoxicity.