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Anticholinergic Drugs

神经

关键词神经 治疗药物 临床用药

词汇介绍

拓展阅读

解析

anticholinergic    英 [,æntɪ,kəʊlɪ'nɜːdʒɪk]   [,ænti,kolə'nɝdʒɪk] 

       adj. 反副交感神经生理作用的;制止副交感神经系统冲动的药剂

       To evaluate the application of anticholinergic agents, theoclears and expectorants in the clinic. 评价抗胆碱能类药物和茶碱制剂以及祛痰药的临床应用情况。

 

drugs   英   [drʌgz] 

            n. 毒品,[] 药物

同近义词     n. 毒品,药物  pharmaceutical , medication

             But with these new you talk about some of the cancer drugs.  但随着这些新的你所说的一些抗癌药物。

概述

抗胆碱能药物与胆碱受体结合后,并不产生或较少产生拟胆碱作用,却能妨碍胆碱能神经递质或外源性拟胆碱药与受体的结合,从而产生抗胆碱作用,表现为胆碱能神经被抑制的种种效应。分类M胆碱受体阻断剂:该类药物能选择性地阻断节后M胆碱能受体,因而能对抗乙酰胆碱和各种拟胆碱药的毒蕈碱样作用,表现为多种平滑肌松驰、腺体分泌抑制,心率加速,瞳孔散大等。该类药物中以阿托晶,东莨菪碱和654-2为代表。N胆碱受体阻断剂:(1)神经节阻断药:如六烃季铵,美加明等,能选择性地阻断神经节内N1胆碱受体,表现为血压下降,临

Patterns of Dementia Treatment and Frank Prescribing Errors in Older Adults With Parkinson Disease复制标题

老年帕金森病患者的痴呆治疗模式和弗兰克处方错误

发表时间:2018-10-01

影响因子:12.2

作者: Sneha Mantri

期刊:JAMA Neurology

Large-scale data on dementia medication use are necessary to define the clinical scope of the problem of dementia in Parkinson disease, but identifying patterns of ineffective dementia medication use or reversible contributors to cognitive dysfunction has the potential to reduce symptom burden and alter the clinical trajectory of Parkinson disease. Acetylcholinesterase inhibitors (ACHEIs) improve cognition by increasing cholinergic activity and include the most widely used dementia drug in the world, donepezil hydrochloride,as well as rivastigmine tartrate and galantamine hydrobromide. Drugs that block cholinergic transmission or have anticholinergic activity are prescribed by all clinical specialties; these drugs include some of the most commonly used in the United States, such as oxybutynin chloride, paroxetine hydrochloride, and diphenhydramine hydrochloride. In the general adult population, anticholinergic medication use is associated with worse performance on cognitive testing,increased risk of dementia, falls,diminished health-related quality of life, and higher health service utilization. Patients with Parkinson disease may be even more vulnerable to the adverse effects of anticholinergic drugs because of the disease-related disruption of central cholinergic pathways.

译文

有关痴呆药物使用的大规模数据对于确定帕金森病痴呆症问题的临床范围是必要的,但确定无效痴呆药物使用模式或认知功能障碍的可逆因素有可能减轻症状负担并改变临床轨迹帕金森病乙酰胆碱酯酶抑制剂(ACHEIs)通过增加胆碱能活性来改善认知,包括世界上使用最广泛的痴呆药物盐酸多奈哌齐,以及酒石酸利凡斯的明和氢溴酸加兰他敏。所有临床专科都规定了阻断胆碱能传递或具有抗胆碱能活性的药物;这些药物包括美国最常用的一些药物,如盐酸奥昔布宁,盐酸帕罗西汀和盐酸苯海拉明。在一般成年人群中,抗胆碱能药物的使用与认知测试的表现更差,痴呆症风险增加,跌倒,健康相关的生活质量下降以及更高的卫生服务利用率相关。患有帕金森病的患者可能更容易受到抗胆碱能药物的不利影响,因为中心胆碱能途径的疾病相关性破坏。