神经
词汇介绍
拓展阅读
解析
deferoxamine
释 义 n. 去铁胺
例 句 Objective :To study the neuroprotective effect of deferoxamine on hypoxic-ischemic brain injury in neonatal rat. 目的研究去铁胺对新生大鼠缺氧缺血性脑病(HIE)模型脑损伤的保护作用。
概述
概述
为一种络活剂,可与铁离子和铝离子形成稳定的水溶性铁胺复合物和铝胺复合物。
临床应用
用于慢性铁负荷过度、急性铁中毒的辅助治疗、慢性肾衰竭伴有铝负荷过度引起的脑病、骨病和贫血而需做透析的患者;亦可用于诊断铁或铝负荷过度。
用法用量
成人:im.慢性铁负荷过度,1日0.5~1 g;急性铁中毒,首次0.5~1 g,隔4h再给0.5 g,以后根据病情每4~12 h 1次,24 h总量不超过6 g;诊断铁负荷过度,排空膀胱内残余尿后注射0.5 g。ih.慢性铁负荷过度,平均日剂量为20~60 mg/kg,最大剂量为1日55 mg/kg;肾衰竭伴铝负荷过度,5 mg/kg,qw。iv gtt.急性铁中毒,1次0.5 g,滴注速度不超过15 mg/(kg·h),用药4~6 h后可适当减慢滴速,24 h总剂量不超过80 mg/kg。小儿:iv gtt.急性铁中毒,20 mg/kg,滴注速度不超过15 mg/(kg·h);ih.慢性铁负荷过度,1日10 mg/kg,腹壁皮下注射8~12 h或24 h,平均日剂量不应超过40 mg/kg。
注意事项
无尿或严重肾功能不全者禁用;肾盂肾炎患者、有听力和视觉障碍者慎用;铁复合物排出时,可使尿液呈红色。
给药说明
皮下注射时浓度不超过10%;皮下注射时针头不能离真皮层太近。
丙泊酚而非七氟醚通过限制肝缺血/再灌注损伤中hif-1 α 的激活来预防线粒体功能障碍和氧化应激
发表时间:2016-07-01
影响指数:5.7
作者: Francesco Bellanti
期刊:Free Radic Biol Med
Mitochondrial dysfunction, reactive oxygen species (ROS) production and oxidative stress during reperfusion are determinant in hepatic ischemia/reperfusion (I/R) injury but may be impacted by different anesthetic agents. Thus, we aimed at comparing the effects of inhaled sevoflurane or intravenous propofol anesthesia on liver mitochondria in a rodent model of hepatic I/R injury. To this, male Wistar rats underwent I/R surgery using sevoflurane or propofol. In the I/R model, propofol limited the raise in serum aminotransferase levels as compared to sevoflurane. Mitochondrial oxygen uptake, respiratory activity, membrane potential and proton leak were altered in I/R; however, this impairment was significantly prevented by propofol but not sevoflurane.
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