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首页 > 医学词汇大全 > Gadopentetate Dimeglumine
Gadopentetate Dimeglumine

神经

关键词神经 治疗药物 造影剂

词汇介绍

拓展阅读

解析

gadopentetate

释    义   钆喷酸

例    句   Objective:To revalue the bad reaction and safety of gadopentetate dimeglumine MRI contrast. 目的:评价磁共振成像钆对比剂的不良反应和安全性。


dimeglumine

释    义   二甲葡胺

例    句   Gadopentetate dimeglumine causes one case of serious laryngeal oedema and shock.钆喷酸葡胺引起严重过敏性休克喉水肿1例。

概述

钆喷酸葡胺(Gd-DTPA)是目前核磁共振成像(MRI)增强检查中最常用的顺磁性造影剂,进入体内后能缩短组织中质子的T1及T2驰豫时间,从而增强图像的清晰度和对比度。用于中枢神经(脑及脊髓)、腹、胸、盆腔、四肢等人体脏器和组织的磁共振成像。不良反应的发生机制自1988年开始,钆喷酸葡胺注射液在美国经过FDA批准应用于临床,不良反应发生率范围在0.17%~2.4%。本文检索到的国内近十年的发表文献不良反应发生率为0.12%~1.17%,低于国外钆喷酸葡胺注射液的不良反应发生率。Gd-DTPA

Case 273复制标题

案例273

发表时间:2019-09-01

影响因子:7.6

作者: Hector N Aguilar

期刊:Radiology

History A 55-year-old man with a history of chronic pancreatitis secondary to chronic alcohol abuse presented to the hospital with acute abdominal pain, generalized weakness, weight loss, and pyrexia. A clinical examination revealed he was tender to touch in the upper abdomen. Laboratory tests revealed a serum alkaline phosphatase level of 370 U/L (6.1 µkat/L) (normal range, 30-130 U/L [0.5-2.2 µkat/L]), a lipase level of 172 U/L (2.9 µkat/L) (normal range, 0-60 U/L [0-1.0 µkat/L]), a C-reactive protein level of 159 mg/L (1514 nmol/L) (normal value, <8.0 mg/L [76.2 nmol/L]), and a white cell count of 7 × 10/L (normal range, [4-11] × 10/L). During the present admission, the patient underwent urgent CT for his acute symptoms.Figure 1a: Images from axial fat-suppressed T2-weighted MRI (repetition time msec/echo time msec, 1000/87; section thickness, 6 mm) of the upper abdomen obtained 2 months prior to admission. Images from axial fat-suppressed T1-weighted MRI (3.69/1.62; section thickness, 4 mm) of the upper abdomen acquired 60 seconds after intravenous administration of gadopentetate dimeglumine (0.1 mL per kilogram of body weight; Magnevist; Bayer Healthcare, East Mississauga, Ontario) during the current admission.

译文

一位55岁的男性,患有慢性酒精滥用继发慢性胰腺炎病史,该院以急性腹痛、全身无力、体重减轻和发热为表现。一项临床检查显示他上腹部触痛。实验室检测显示血清碱性磷酸酶水平为370 U/L(6.1μkat/L)(正常范围30-130 U/L[0.5-2.2μkat/L]),脂肪酶水平为172 U/L(2.9μkat/L)(正常范围0-60 U/L[0-1.0μkat/L]),C-反应蛋白水平为159 mg/L(1514 nmol/L)(正常值<8.0 mg/L[76.2 nmol/L]),白细胞计数为7×10/L(正常范围,[4-11]×10/L)。在入院时,病人接受了紧急CT检查以显示急性症状。图1a:在入院前2个月,轴向脂肪抑制的T2加权像(重复时间为毫秒/回声时间为1000/87毫秒,断面厚度为6毫米)。从轴向脂肪抑制的T1加权MRI(3.69/1.62;节段厚度,4毫米)的上腹部获得静脉注射钆喷酸二甲葡胺(每公斤体重0.1毫升;MixVistt;拜耳医疗保健,东米西索加,安大略)在当前入院时60秒。