微信扫码关注“小狗文献”

即刻体验更多权益

文献多,下载快,翻译准

首页 > 医学词汇大全 > Dipyridamole
Dipyridamole

神经

关键词神经 治疗药物 扩张血管

词汇介绍

拓展阅读

解析

dipyridamole    英 [,daɪpɪ'rɪdəməʊl] 美 [daɪ'pɪrɪdə,mol; daɪ'pə'rɪdə,mol] 

释    义   n. 双嘧达莫

例    句   To investigate the protective effect and mechanism of dipyridamole against ischemia-reperfusioninjury on rabbit liver. 探讨潘生丁对兔肝脏热缺血再灌注损伤的保护作用及其相关机制。

概述

主要的药理作用为抑制血小板凝集和扩张血管。本品能增加冠状动脉血流量,但不增加心肌耗氧量,并能减少血小板的凝聚性。临床用于冠状动脉供血不足或伴有心绞痛的患者,也可用于防治血栓形成。药动学本品口服后迅速吸收。本品的血药浓度波动较大,普通制剂难以维持较稳定的有效抑制血小板聚集的血药浓度。健康者每日口服200 mg,其血药浓度波动于1.8-5.6 μmo/L。少量药物可透过胎盘屏障,分布于乳汁。血浆蛋白结合率高达97%-99%。药物与在肝内与葡萄糖醛酸结合后排入胆汁,进人小肠后被再吸收入血,故作用较

Age- and Gender-Specific Prognostic Cutoff Values of Coronary Flow Velocity Reserve in Vasodilator Stress Echocardiography复制标题

血管扩张剂负荷超声心动图冠状动脉血流速度储备的年龄和性别特异性预后截断值

发表时间:2019-10-01

影响因子:6.1

作者: Lauro Cortigiani

期刊:J Am Soc Echocardiogr

PURPOSE:Coronary flow velocity reserve (CFVR) of the left anterior descending artery is useful for risk stratification during stress echocardiography (SE) as an add-on to regional wall motion abnormalities (RWMA). We sought to provide sex- and age-specific prognostic cutoff values for CFVR.METHODS:A total of 5,577 patients (2,284 women; 110 age ≥ 85 years) who underwent dipyridamole SE with evaluation of RWMA and CFVR were enrolled in a multicenter prospective SE registry. Death and myocardial infarction were the clinical end points.RESULTS:During 20 months' median follow-up, 649 events (236 deaths, 413 infarctions) occurred: 288 in women and 38 in patients ≥85 years. At receiver operating characteristics analysis, the best prognostic cutoff value for CFVR was similar for men (2.03) and women (2.02) and consistent across all age strata (<45 years: 2.03; 45-54 years: 2.04; 45-64 years: 2.03; 65-74 and 75-84 years: 2.0) except for patients >85 years, who showed 1.90 as the optimal value.

译文

目的:左前降支冠状动脉血流速度储备(cfvr)作为局部室壁运动异常(rwma)的补充,有助于超声心动图(se)的危险分层。我们试图为cfvr提供性别和年龄特异性的预后临界值。方法:对5577例(2284例女性,110例年龄≥85岁)经雷公藤多中心前瞻性se登记的患者进行rwma和cfvr评价。死亡和心肌梗死是临床终点。结果:在20个月的中位随访中,共发生649例事件(236例死亡,413例梗死),其中女性288例,85岁以上患者38例。在受试者操作特征分析中,cfvr的最佳预后临界值对于男性(2.03)和女性(2.02)是相似的,并且在所有年龄层(<45岁:2.03;45-54岁:2.04;45-64岁:2.03;65-74和75-84岁:2.0)都是一致的,除了那些显示1.90为最佳值的大于85岁的患者。