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首页 > 医学词汇大全 > Troxerutin
Troxerutin

神经

关键词神经 治疗药物 防血栓

词汇介绍

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解析

troxerutin

释    义   曲克芦丁

例    句   To establish a method for the determination of other hydroxyethylated rutin derivatives in troxerutin for injection by HPLC. 建立了高效液相色谱法测定注射用曲克芦丁中其他羟乙基芦丁衍生物的方法。

概述

作用与用途药效学:本药是芦丁经羟乙基化半合成水溶性黄酮类化合物,对闭塞性血管病具有较好的疗效。药理作用:①抑制血小板聚集,防止血栓形成。②对抗5-羟色胺、缓激肽引起的血管损伤,增加毛细血管抵抗力,降低毛细血管通透性,从而防止血管通透性增高引起的水肿。③增加血氧含量和氧饱和度,促进新血管生成以增进侧支循环,对急性缺血性脑损伤有显著的保护作用。④可兴奋神经纤维,具有解痉作用。⑤还具有抗放射线损伤、抗炎症、抗过敏、抗溃疡等作用。药动学:口服吸收良好,给药后1~6小时达血药浓度峰值。药物体内分布广泛,可

Troxerutin down-regulates KIM-1, modulates p38 MAPK signaling, and enhances renal regenerative capacity in a rat model of gentamycin-induced acute kidney injury复制标题

曲克芦丁在庆大霉素诱导的急性肾损伤大鼠模型中下调KIM-1,调节p38 MAPK信号,增强肾脏再生能力

发表时间:2018-12-13

影响因子:3.2

作者: Samir A. Salama

期刊:Food Funct

Gentamycin is an aminoglycoside antibiotic that is widely employed for controlling Gram negative bacterial infections including that caused by the antibiotic-resistant Pseudomonas species. The clinical use of gentamycin is substantially limited by its side effects particularly acute kidney injury (AKI). The aim of the current study was to investigate the protective effect of the plant flavonoid troxerutin (150 mg kg-1 day-1 for 15 days) against gentamycin-induced AKI using Wistar rats as an experimental mammalian model. The results of the present work revealed that troxerutin significantly improved renal function as demonstrated by the increase in the glomerular filtration rate and the decrease in the levels of urinary albumin, urinary albumin to creatinine ratio, serum creatinine, and blood urea nitrogen (p < 0.001). In addition, troxerutin significantly attenuated gentamycin-induced renal tissue injury as indicated by the decreased protein expression of the renal tubular injury marker KIM-1, the attenuation of the renal histopathological changes, and the modulation of the oxidative stress markers as reflected by the decrease in the levels of lipid and protein oxidative modifications and the increase in the levels of reduced glutathione and total antioxidant capacity (p < 0.001).

译文

庆大霉素是一种氨基糖苷类抗生素,广泛应用于控制革兰阴性菌感染,包括耐药假单胞菌引起的感染。庆大霉素的临床应用受到其副作用特别是急性肾损伤(aki)的严重限制。本研究以wistar大鼠为实验动物模型,观察植物黄酮曲克芦丁(150mg kg-1d-1d-15d)对庆大霉素诱导的aki的保护作用。结果表明,曲克芦丁能显著改善肾功能,表现为肾小球滤过率升高,尿白蛋白、尿白蛋白与肌酐比值、血清肌酐和血尿素氮水平降低(p<0.001)。此外,曲克芦丁明显减轻庆大霉素肾组织损伤,如肾小管损伤标志物KIM-1蛋白表达降低、肾组织病理学改变减弱和氧化应激标志物的调节,如脂质和蛋白质水平降低所反映的。氧化修饰和还原型谷胱甘肽水平和总抗氧化能力的增加(P<0.001)。