thrombin 英 ['θrɒmbɪn] 美 ['θrɑmbɪn]
释 义 n. [生化] 凝血酶
例 句 The ultimate result is the formation of the thrombin and fibrin clot, and each enzymolysisaccompaniment magnify effective. 最终结果是凝血酶和纤维蛋白凝块的形成，而且每步酶解反应均有放大效应。
作者： Amanda Bruder Rassi
BACKGROUND AND AIMS:The efficacy of fresh frozen plasma (FFP) transfusion in enhancing thrombin generation in patients with cirrhosis and impaired conventional coagulation tests has not been sufficiently explored.METHODS:Fifty-three consecutive patients receiving a standard dose of FFP to treat bleeding and/or before invasive procedures if prothrombin time (PT) ratio-INR was ≥1.5 were prospectively enrolled. Primary endpoint was the amelioration of endogenous thrombin potential (ETP) with thrombomodulin (ETP-TM) after transfusion, which corresponds to the total amount of generated thrombin. PT-INR, aPTT were also assessed before and after transfusion.RESULTS:FFP enhanced ETP-TM by 5.7%, from 973 [731-1258] to 1028 [885-1343] nM x min; p= 0.019). Before transfusion, evidence of normal or high ETP-TM was found in 94% of patients, even in those with bacterial infections. Only 1 (1.9%) patient had ETP-TM values reverting to the normal range after transfusion. Notably, no patients with low ETP-TM had bleeding. The median decrease in ETP-TM was 8.3% and the mean was 12.8% in 18 (34%) after transfusion (from 1225 [1071-1537] to 1124 [812-1370] nM x min; p=<0.0001). Similar responses to FFP transfusion were observed in patients with compensated and acute descompensated cirrhosis, ACLF, infection or shock. FFP significantly ameliorated INR and aPPT values (p < 0.0001), but in a minority of patients the values were reduced to less than the cut-off point of 1.5.