摘要

To study the potential association of antidepressant use and suicide at a population level, we analyzed the associations between suicide rates and dispensing of the prototypic SSRI antidepressant fluoxetine in the United States during the period 1960-2002.Sources of data included Centers of Disease Control and US Census Bureau age-adjusted suicide rates since 1960 and numbers of fluoxetine sales in the US, since its introduction in 1988. We conducted statistical analysis of age-adjusted population data and prescription numbers. Suicide rates fluctuated between 12.2 and 13.7 per 100,000 for the entire population from the early 1960s until 1988. Since then, suicide rates have gradually declined, with the lowest value of 10.4 per 100,000 in 2000. This steady decline is significantly associated with increased numbers of fluoxetine prescriptions dispensed from 2,469,000 in 1988 to 33,320,000 in 2002 (r(s) = -0.92; p < 0.001). Mathematical modeling of what suicide rates would have been during the 1988-2002 period based on pre-1988 data indicates that since the introduction of fluoxetine in 1988 through 2002 there has been a cumulative decrease in expected suicide mortality of 33,600 individuals (posterior median, 95% Bayesian credible interval 22,400-45,000).The introduction of SSRIs in 1988 has been temporally associated with a substantial reduction in the number of suicides. This effect may have been more apparent in the female population, whom we postulate might have particularly benefited from SSRI treatment. While these types of data cannot lead to conclusions on causality, we suggest here that in the context of untreated depression being the major cause of suicide, antidepressant treatment could have had a contributory role in the reduction of suicide rates in the period 1988-2002.

译文

为了研究在人群层面使用抗抑郁药和自杀的潜在关联,我们分析了 1960-2006 年期间美国自杀率与原型 SSRI 抗抑郁药氟西汀的分配之间的关系。数据来源包括疾病控制中心和美国人口普查局自 1960年和氟西汀在美国的销售数量, 自 1988年推出以来。我们对年龄调整后的人口数据和处方号进行了统计分析。从 1960年初到 1988年,整个人口的自杀率在每 12.2 人 13.7 到 100,000 人之间波动。从那以后,自杀率逐渐下降,2000年的最低值为每 10.4 人中有 100,000 人。这种稳步下降与氟西汀处方数量的增加显著相关,从 1988年的 2,469,000 张增加到 2002年的 33,320,000 张 (r (s) =-0.92; p <0.001)。数学建模的自杀率会有什么 pre-1988 一直在 1988-2002 期间的数据表明,氟西汀于 1988年到 2002年以来已累计减少预期的自杀死亡 33,600 个体 (后正中,95% 贝叶斯可信区间 22,400-45,000)。1988年 SSRIs 的引入暂时与自杀数量的大幅减少有关。这种影响在女性人群中可能更加明显,我们假设她们可能特别受益于 SSRI 治疗。虽然这些类型的数据不能得出因果关系的结论,但我们在此建议,在未经治疗的抑郁症是自杀的主要原因的背景下, 抗抑郁治疗本可以在 1988 至 2002 期间降低自杀率中起作用。

Fluoxetine

神经 精神类药物 治疗药物
概述  :  

本品主要治疗各种抑郁性精神障碍、包括轻性或重性抑郁症、双相情感性精神障碍的抑郁症,心因性抑郁及抑郁性神经症。氟西汀能有效改善SPS大鼠的症状恐惧、焦虑、及探究行为等症状,提高动物的学习记忆能力。机制氟西汀通过作用于 5-HT 受体发挥治疗作用,血清素(5-羟色胺,5-HT)及其受体与精神疾病密切相关,如抑郁、焦虑,冲动行为和酒精依赖等。动物模型的研究发现压力可以影响 5-HT 的表达,导致动物行为异常。5-HT1A 受体主要分布在中缝核,以及边缘系统,这些区域参与情感调节

fluoxetine   ['fluəksiti:n] 

释    义   n. 氟苯氧丙胺;氟西汀

例    句   Conclusion The quetiapine combined fluoxetine is effective and safe in the treatment of depression disorders. 结论奎的平合用氟西汀治疗重性抑郁障碍疗效较好且安全性高。

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