RATIONALE AND OBJECTIVES:The authors compared the effects of a nonionic monomeric, iohexol (Omnipaque, 300 mg I/ml), and a nonionic dimeric, iotrolan (Isovist, 300 mg I/ml), contrast medium in the spinal subarachnoid space of the pig. METHODS:Lumbar and lateral C1-C2 punctures were performed in 10 pigs. Ten milliliters iohexol or iotrolan were injected via the lumbar needle. Blood pressure, electrocardiogram, intravesical pressure, and cerebrospinal fluid pressure were recorded during the injections and at intervals for 4 to 5 hours after the injections. Blood samples were taken at 30, 60, 120, 180, 240, and 300 minutes after the injections and analyzed for iodine concentration. RESULTS:No changes were seen during the injections, and there were no differences in the blood pressure, cerebrospinal fluid pressure, electrocardiographic recordings, or in the plasma iodine concentrations during the first 4 to 5 hours after the injections. Short-lasting, rhythmic bladder contractions were seen during some injections with both iohexol and iotrolan. CONCLUSION:Both iohexol and iotrolan were well tolerated, and there was no significant difference between them. and there was no significant difference between them.
原理和目的: 作者比较了非离子单体、碘海醇 (Omnipaque，300 mg I/ml) 和非离子二聚、碘trolan (Isovist, 300 mg I/ml)，对比液于猪脊髓蛛网膜下腔。 方法: 对 10 只猪进行腰椎和外侧 C1-C2 穿刺。通过腰针注射 10 毫升碘海醇或碘氯。在注射期间和注射后 4 至 5 小时间隔记录血压、心电图、膀胱内压和脑脊液压。在注射后 30 分钟、 60 分钟、 120 分钟、 180 分钟、 240 分钟、 300 分钟和分钟采集血样，并分析碘浓度。 结果: 注射过程中未见变化，血压、脑脊液压、心电图记录无差异, 或者在注射后的最初 4 到 5 小时内血浆中的碘浓度。在一些注射碘海醇和碘氯的过程中，可以看到短暂的、有节奏的膀胱收缩。 结论: 碘海醇和碘trolan 均具有良好的耐受性，两者之间无显著差异。它们之间没有显著差异。
Animal experimental myelography in the pig. A comparison between iohexol and iotrolan.
碘曲仑是造影药的一种，主要用于椎管造影、脑室造影，以及各种瘘管、腔道造影。碘曲仑非离子型双聚体碘水造影剂。药代动力学本品口服后不吸收。血管内给药和鞘内给药的药代动力学特征与碘海醇相似。静脉给药后几乎均匀分布于细胞外液，24h尿排出率近100%；鞘内给药后，药物缓慢扩散至血液，血浆浓度平均为给药量的6%。1-2 h达高峰，t1/2为4 h，3d后90%从尿中排出，1%从粪便排出。用法脊髓造影、脑室造影、脑池造影时对比剂的用量和浓度取决于X线设备，如能不搬动患者，即以各种所需体位投
释 义 碘曲仑
短 语 Iotrolan Injection 碘曲仑注射液
例 句 Comparison of Nephrotoxicity of Diatrizoate and Iotrolan in Diabetic Rats.