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首页 > 医学词汇大全 > Iotrolan
Iotrolan

神经

关键词神经 疾病 造影剂

词汇介绍

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解析

Iotrolan

释    义   碘曲仑

短    语   Iotrolan Injection 碘曲仑注射液

例    句   Comparison of Nephrotoxicity of Diatrizoate and Iotrolan in Diabetic Rats.

泛影葡胺和碘曲仑对糖尿病大鼠肾毒性的比较

概述

  碘曲仑是造影药的一种,主要用于椎管造影、脑室造影,以及各种瘘管、腔道造影。碘曲仑非离子型双聚体碘水造影剂。药代动力学本品口服后不吸收。血管内给药和鞘内给药的药代动力学特征与碘海醇相似。静脉给药后几乎均匀分布于细胞外液,24h尿排出率近100%;鞘内给药后,药物缓慢扩散至血液,血浆浓度平均为给药量的6%。1-2 h达高峰,t1/2为4 h,3d后90%从尿中排出,1%从粪便排出。用法脊髓造影、脑室造影、脑池造影时对比剂的用量和浓度取决于X线设备,如能不搬动患者,即以各种所需体位投

Adverse skin reactions to iodinated x-ray contrast agents in healthy rats复制标题

碘化x线造影剂对健康大鼠皮肤的不良反应

发表时间:2014-12-01

影响因子:6.1

作者: Diana C Lenhard

期刊:Invest Radiol

PURPOSE:The aim of this preclinical study on healthy Sprague-Dawley rats was to determine whether differences exist in the induction of adverse skin reactions after the intravenous administration of a monomeric and 2 dimeric iodinated nonionic contrast agents.MATERIALS AND METHODS:After intravenous injection of iopromide (monomeric), iodixanol (dimeric), and iotrolan (dimeric) at a dose of 4 g iodine/kg of body weight, mechanical ear volume measurements (10 minute after injection) and intravital microscopy (baseline, 5 minutes after injection) of the ear with the near-infrared dye indocyanine green were performed to determine the volume change and plasma extravasation. Histopathological analysis (20 minutes, 1 hour, and 3 hours after injection) was performed to diagnose alterations in the skin. Blood plasma was analyzed to identify elevated levels of histamine (5 minutes after injection) and inflammatory markers (a multianalyte profile of 58 markers; 1 hour and 3 hours after injection).

译文

目的:健康Sprague Dawley rats的临床前研究的目的是确定在单体和2二聚碘离子非离子造影剂静脉给药后诱导不良皮肤反应是否存在差异。材料和方法:静脉注射碘普罗胺(单体)、碘丙醇(二聚体)和碘罗兰(二聚体)4 g/kg体重后,进行机械耳容积测量(注射后10分钟)和活体显微镜检查(基线检查,注射5分钟后)用近红外染料吲哚菁绿测定耳部容积变化和血浆外渗。进行组织病理学分析(注射后20分钟、1小时和3小时)以诊断皮肤变化。分析血浆以确定组胺(注射后5分钟)和炎症标记物(58个标记物的多分析曲线;注射后1小时和3小时)的升高水平。