神经
词汇介绍
拓展阅读
解析
Iotrolan
释 义 碘曲仑
短 语 Iotrolan Injection 碘曲仑注射液
例 句 Comparison of Nephrotoxicity of Diatrizoate and Iotrolan in Diabetic Rats.
泛影葡胺和碘曲仑对糖尿病大鼠肾毒性的比较
概述
Adverse skin reactions to iodinated x-ray contrast agents in healthy rats复制标题
碘化x线造影剂对健康大鼠皮肤的不良反应
发表时间:2014-12-01
影响因子:6.1
作者: Diana C Lenhard
期刊:Invest Radiol
PURPOSE:The aim of this preclinical study on healthy Sprague-Dawley rats was to determine whether differences exist in the induction of adverse skin reactions after the intravenous administration of a monomeric and 2 dimeric iodinated nonionic contrast agents.MATERIALS AND METHODS:After intravenous injection of iopromide (monomeric), iodixanol (dimeric), and iotrolan (dimeric) at a dose of 4 g iodine/kg of body weight, mechanical ear volume measurements (10 minute after injection) and intravital microscopy (baseline, 5 minutes after injection) of the ear with the near-infrared dye indocyanine green were performed to determine the volume change and plasma extravasation. Histopathological analysis (20 minutes, 1 hour, and 3 hours after injection) was performed to diagnose alterations in the skin. Blood plasma was analyzed to identify elevated levels of histamine (5 minutes after injection) and inflammatory markers (a multianalyte profile of 58 markers; 1 hour and 3 hours after injection).
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