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首页 > 医学词汇大全 > adoptive cellular immunotherapy
adoptive cellular immunotherapy

免疫

关键词免疫 治疗方法 过继免疫细胞治疗

词汇介绍

拓展阅读

解析

adoptive  英  /əˈdɒptɪv/  美  /əˈdɑːptɪv/

释    义   adj. 采用的;有收养关系的

例    句   He was brought up by adoptive parents in Kentucky.他是被他在肯塔基州的养父母抚养大的。

 

cellular  英  /ˈseljələ(r)/  美  /ˈseljələr/

释    义   n. 移动电话;单元;

               adj. 细胞的;多孔的;由细胞组成的

例    句   Many toxic effects can be studied at the cellular level.许多毒性作用在细胞阶段就可加以研究。

 

immunotherapy  英  /,ɪmjʊnəʊ'θerəpɪ; ɪ,mjuːnəʊ-/  美  /ɪ'mjəno'θɛrəpi/

释    义   n. 免疫疗法

例    句   For the time being, however, immunotherapy is still in its experimental stages.然而,目前免疫疗法还处于试验阶段。

概述

  肿瘤过继免疫治疗是指通过向肿瘤患者输注具有抗肿瘤活性的免疫细胞,直接杀伤或激发机体免疫反应杀伤肿瘤细胞,达到治疗肿瘤的目的。它包括非特异性激活和特异性激活的效应细胞,前者是采用非特异性刺激因子(IL-2、干扰素)刺激前体效应细胞,使其活化为具有抗肿瘤活性的效应细胞,如LAK细胞、肿瘤浸润性淋巴细胞(TIL)、细胞因子诱导的杀伤细胞等;特异性激活的效应细胞是指采用肿瘤抗原作刺激物所诱导的抗肿瘤效应细胞,如树突状细胞(DC)、细胞毒T淋巴细胞(CD8+细胞)等。

Simple in vitro generation of human leukocyte antigen-G-expressing T-regulatory cells through pharmacological hypomethylation for adoptive cellular immunotherapy against graft-versus-host disease复制标题

通过药理学低甲基化简单体外生成人类白细胞抗原-G-调节细胞用于移植物抗宿主病的过继性细胞免疫治疗

发表时间:2017-04-19

影响因子:4.2

作者: Stamou P

期刊:Cytotherapy

Major barriers in using classical FOXP3+ regulatory T cells (Tregs) in clinical practice are their low numbers in the circulation, the lack of specific cell surface markers for efficient purification and the loss of expression of Treg signature molecules and suppressive function after in vitro expansion or in a pro-inflammatory microenviroment. A surface molecule with potent immunosuppressive function is the human leukocyte antigen-G (HLA-G), which is normally expressed in placenta protecting the "semi-allogeneic" fetus from maternal immune attack. Because HLA-G expression is strongly regulated by methylation, we asked whether hypomethylating agents (HA) may be used in vitro to induce HLA-G expression on conventional T cells and convert them to Tregs. Human peripheral blood T cells were exposed to azacytidine/decitabine and analyzed for HLA-G expression and their in vitro suppressor properties. HA treatment induces de novo expression of HLA-G on T cells through hypomethylation of the HLA-G proximal promoter. The HA-induced CD4HLA-G T cells are FOXP3 negative and have potent in vitro suppression function, which is dependent to a large extent, but not exclusively, on the HLA-G molecule.

译文

主要障碍在使用古典FOXP3 +调节性T细胞亚群)在临床实践中较低的数字循环,缺乏特定的细胞表面标记的高效净化和Treg信号分子的表达和抑制功能后体外或炎性microenviroment扩张。人类白细胞抗原g (HLA-G)是一种具有强大免疫抑制功能的表面分子,通常在胎盘中表达,保护“半异基因”胎儿免受母体免疫攻击。由于HLA-G表达受到甲基化的强烈调控,我们询问是否可以在体外使用低甲基化剂(HA)诱导常规T细胞上的HLA-G表达并将其转化为treg。将人外周血T细胞暴露于azacytidine/decitabine中,分析HLA-G的表达及其体外抑制特性。HA处理通过HLA-G近端启动子的低甲基化诱导HLA-G在T细胞上的从头表达。ha诱导的CD4HLA-G T细胞FOXP3阴性,在体外具有强大的抑制功能,这在很大程度上依赖于HLA-G分子,但并不完全依赖于HLA-G分子。