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首页 > 医学词汇大全 > immunoglobulin G4-related sclerosing cholangitis (IgG4-SC)
immunoglobulin G4-related sclerosing cholangitis (IgG4-SC)

免疫

关键词免疫 疾病 免疫球蛋白G4相关硬化性胆管炎

词汇介绍

拓展阅读

解析

immunoglobulin 英  /,ɪmjʊnəʊ'glɒbjʊlɪn; ɪ,mjuːnəʊ-/  美  /,ɪmjəno'glɑbjələn/

释    义   n. [免疫][生化] 免疫球蛋白;免疫血球素

例    句   These abnormal LPL cells produce large amounts of the protein immunoglobulin and macroglobulin.这些异常的LPL细胞产生大量的蛋白免疫球蛋白和巨球蛋白。

 

sclerosing  英  /skliə'rəusiŋ/  美  /skliə'rəusiŋ/

释    义   adj. 致硬化的,硬化型的;

               v. (使)硬化,引起……的硬化(sclerose的现在分词形式)

例    句   Subacute sclerosing panencephalitis (SSPE) is a very rare, progressive neurological disorder.亚急性硬化性全脑炎(SSPE)是一种十分罕见的进行性的神经疾患。

 

cholangitis  英  /,kɔlən'dʒaitis/  美  /,kɔlən'dʒaitis/

释    义   n. 胆道炎,[内科] 胆管炎

例    句   This trichrome stain of the liver demonstrates extensive portal tract fibrosis with sclerosing cholangitis. The hepatocytes are normal.肝脏三色染色显示硬化性胆管炎时,广泛的门管区纤维化。肝细胞正常。

概述

  IgG4相关性疾病(IgG4-related disease,IgG4-RD)是一种免疫相关的全身性疾病,以组织中大量IgG4阳性浆细胞浸润、纤维化及闭塞性静脉炎为主要病理特征,可累及胰腺、胆管、肝脏、后腹膜、泪腺、唾液腺、淋巴结、肾脏、肺、心脏等全身多个组织器官。IgG4相关硬化性胆管炎(IgG4-related sclerosing cholangitis,IgG4-SC)特指IgG-RD累及胆管的表现,可以单独出现或者与其他IgG4-RD同时出现。最初该

Successful treatment with rituximab of IgG4-related disease coexisting with adult-onset asthma and periocular xanthogranuloma.复制标题

利妥昔单抗成功治疗IgG4-related病合并成人型哮喘和眼周黄色肉芽肿。

发表时间:2020-04-04

影响因子:2.0

作者: Asproudis I

期刊:Rheumatol Int

Immunoglobulin G4-related disease (IgG4RD) is a systemic fibro-inflammatory disease of unknown aetiology, which is characterized by tumefactive lymphoplasmatocytic infiltrative lesions, with a predominance of IgG4 positive plasma cells, fibrosis and obliterative phlebitis. Adult-onset asthma and periocular xanthogranuloma (AAPOX) is a rare disease of unknown aetiology characterized by violaceous or yellow cutaneous papules and nodules usually accompanied with adult-onset asthma. We report a case of IgG4RD associated with AAPOX. We also conducted a literature search with keywords including IgG4RD and AAPOX. A 36-year-old woman presented with bilateral exophthalmos and periorbital oedema. Keratoconjunctivitis sicca, painless left parotid gland and submandibular left lymph node enlargement were also noted. Two and half years ago biopsy of yellow plaques of her right lower eyelid confirmed periorbital xanthogranuloma. She underwent parotid gland biopsy which showed IgG4RD.

译文

IgG4RD (Immunoglobulin G4-related disease, IgG4RD)是一种病因不明的全身性纤维炎性疾病,以tumefactive lymphoplasmatocytic浸润性病变为特征,以IgG4阳性浆细胞为主,并伴有纤维化和闭塞性静脉炎。成人发病的哮喘和眼周黄色肉芽肿(AAPOX)是一种病因不明的罕见疾病,以紫色或黄色皮肤丘疹和结节为特征,通常伴有成人发病的哮喘。我们报告一例与AAPOX相关的IgG4RD。我们还进行了文献搜索,关键词包括IgG4RD和AAPOX。摘要一位36岁妇女,以双侧眼球突出及眼眶周围水肿为表现。角膜结膜炎sicca,无痛的左腮腺和下颌下左淋巴结肿大。两年半前,她右下眼睑的黄色斑块活检证实眶周黄色肉芽肿。她接受了腮腺活检显示为IgG4RD。