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首页 > 医学词汇大全 > erythrocyte immune adhesion promoter
erythrocyte immune adhesion promoter

免疫

关键词免疫 临床研究术语 红细胞免疫粘附促进因子

词汇介绍

拓展阅读

解析

erythrocyte  英  /ɪˈrɪθrəsaɪt/  美  /ɪˈrɪθrəsaɪt/

释    义   n. [细胞] 红细胞;[细胞] 红血球

例    句   There are numerous inherited antigens on the surface of the human erythrocyte.在人的红细胞表面上存在许多遗传的抗原。

 

immune  英  /ɪˈmjuːn/  美  /ɪˈmjuːn/

释    义   n. 免疫者;免除者;

               adj. 免疫的;免于……的,免除的

例    句   No one should be immune from prosecution.任何人都不应免于被起诉。

 

adhesion 英  /ədˈhiːʒn/  美  /ədˈhiːʒn/

释    义   n. 粘附;黏附(力);支持;固定;

例    句   Better driving equipment will improve track adhesion in slippery conditions.更好的驱动装置能在湿滑的条件下提高轨道的附着力。

 

promoter 英  /prəˈməʊtə(r)/  美  /prəˈmoʊtər/

释    义   n. 促进者;发起人;催化剂;促进剂;启动子

例    句   Aaron Copland was always the most energetic promoter of American music.阿伦·柯普兰一直是是美国音乐最积极的倡导者。

概述

  1987年郭峰通过体外对比实验证明血清中还存在一种加热(58℃30')不灭活的红细胞免疫粘附促进因子,说明红细胞免疫功能高低本身也存在调控机理。临床与科研证明肿瘤患者和创伤者红细胞免疫促进因子是下降的。而且在创伤研究中发现其下降与抑制因子上升呈反向,说明同时研究这两种红细胞免疫调节因子变化规律,更能阐明在病态时红细胞免疫功能调控失常的具体机理。   血清中红细胞免疫粘附促进因子的测定材料和方法   1.补体致敏酵母多

Heme Oxygenase-1 Polymorphism Is Associated With the Development of Necrotic Acute Pancreatitis Via Vascular Cell Adhesion Molecule-1 and the E-Selectin Expression Regulation Pathway.复制标题

血红素Oxygenase-1基因多态性通过血管细胞黏附分子-1和E-选择素表达调控途径与坏死性急性胰腺炎的发生发展相关。

发表时间:2019-07-06

影响因子:2.9

作者: Gulla A

期刊:Pancreas

Severe acute pancreatitis can lead to systemic complications. Here, we explore the mechanisms based on our previous study associated with the deregulation of heme oxygenase-1 (HO-1) and development of severe acute pancreatitis. Acute pancreatitis patients (n = 135) and age- and sex-matched healthy controls (n = 108) were studied. The polymerase chain reaction products were analyzed with an ABI 3130 genetic analyzer and GeneMapper software. A short allele was defined ≤ 27 dinucleotide (GT) repeats, whereas a long allele was defined >27 GT. Levels of 12 different cytokines in blood serum were measured by enzyme-linked immunosorbent assay. All samples in this study were consistently stored in -80°C.Patients with the long long genotype expressed E-selectin and vascular cell adhesion molecule-1 at statistically significantly higher levels in serum compared with short short genotype or short long genotypes. Vascular cell adhesion molecule-1 and E-selectin serum levels significantly correlate with the total allele length of the HO-1 promoter region.

译文

严重的急性胰腺炎可导致全身并发症。在此,我们在前人研究的基础上探讨血红素氧合酶-1 (HO-1)异常与重症急性胰腺炎发生的相关机制。研究了135例急性胰腺炎患者和108例年龄和性别匹配的健康对照组。聚合酶链反应产物用ABI 3130基因分析仪和GeneMapper软件进行分析。短等位基因≤27个二核苷酸(GT)重复,长等位基因>27 GT。用酶联免疫吸附法测定血清中12种细胞因子的水平。本研究中所有样品均在-80℃保存。长-长基因型患者血清中e选择素和血管细胞黏附分子-1表达水平明显高于短-短基因型和短-长基因型患者。血清中血管细胞黏附分子-1和e-选择素水平与HO-1启动子区域的总等位基因长度显著相关。