微信扫码关注“小狗文献”

即刻体验更多权益

文献多,下载快,翻译准

首页 > 医学词汇大全 > immune mediated necrotizing myopathy
immune mediated necrotizing myopathy

免疫

关键词免疫 疾病 免疫介导坏死性肌病

词汇介绍

拓展阅读

解析

immune  英  /ɪˈmjuːn/  美  /ɪˈmjuːn/

释    义   n. 免疫者;免除者;

               adj. 免疫的;免于……的,免除的

例    句   No one should be immune from prosecution.任何人都不应免于被起诉。

 

mediate 英  /ˈmiːdieɪt/  美  /ˈmiːdieɪt/

释    义   adj. 间接的;居间的;

               vi. 调解;斡旋;居中;

               vt. 调停;传达

例    句   The Secretary-General was asked to mediate in the dispute.有人请秘书长来调解这次纷争。

 

necrotizing  英  /'nekrə,taiziŋ/  美  /'nekrə,taiziŋ/

释    义   n. 坏死(necrotize的ing形式);使…坏死;

               adj. 坏死的;引起坏死的

例    句   Lack of oxygen is a factor in the development of necrotizing enterocolitis (nec), a kind of gangrene of the intestine that can be fatal in premature babies.缺氧是坏死性小肠结肠炎(necrotizing enterocolitis, nec),一种对发育未成熟的新生儿来说致命的坏疽,发病的重要因素之一。

 

myopathy 英  /maɪ'ɒpəθɪ/  美  /maɪ'ɑpəθi/

释    义   n. [外科] 肌病

例    句   The most serious form of myopathy is called rhabdomyolysis.肌病最严重的形式被称作横纹肌溶解。

概述

  免疫介导坏死性肌病(NAM)不同于多发性肌炎、皮肌炎、包涵体肌炎及非特异性肌炎,是新近认识的一类特异性炎性肌病(IIM)。20世纪初人们并未认识到NAM是一种独立的肌病,将其归类于多发性肌炎、可疑多发性肌炎或皮肌炎。直到2004年,欧洲神经肌肉疾病中心和美国肌病研究协作组依据NAM的临床特点及肌肉病理表现将其单独分类。此后这一特发性炎症性肌病的新亚型逐渐得到关注,成为研究热点。   病因   1.药物:引

Severe axial and pelvifemoral muscle damage in immune-mediated necrotizing myopathy evaluated by whole-body MRI.复制标题

全身MRI评价免疫介导的坏死性肌病的严重轴肌和股外肌损伤。

发表时间:2020-02-29

影响因子:4.8

作者: Landon-Cardinal O

期刊:Semin Arthritis Rheum

Our objective was to define the pattern and severity of muscle damage in immune-mediated necrotizing myopathy (IMNM) and its relationship with clinical and serological features. IMNM patients with a whole-body MRI (n=42) were included and compared to sporadic inclusion-body myositis (s-IBM) patients (n=60). Fat replacement was estimated using the Mercuri score in 55 muscles. Overall lesion load was defined as the sum of all abnormal Mercuri scores (reported in % maximal score) and lesion load quotient was defined as the overall lesion load divided by disease duration. Linear relationships between variables were assessed and multidimensional analysis was performed to define homogenous groups of patients. IMNM patients were aged 48.1±15.8 years and had a disease duration of 9.8±8.1 years. Most severely affected muscle groups were located in the pelvifemoral and lumbar region. Unsupervised analysis showed two subgroups of patients: one with mild lesion load (15±10%, n=32/42) and another with severe lesion load (60±10%, n=10/42: p<0.001) associated with a mean disease duration of 6.8±6.0 years and 19.5±5.7 years, respectively (p<0.0001).

译文

我们的目的是确定免疫介导坏死性肌病(IMNM)肌肉损伤的模式和严重程度,及其与临床和血清学特征的关系。纳入全身MRI的IMNM患者(42例),并与散发性包涵体肌炎(s-IBM)患者(60例)进行比较。使用Mercuri评分对55块肌肉进行脂肪替代评估。病变负荷定义为所有异常的Mercuri评分(以%最大评分报告)之和,病变负荷商定义为总病变负荷除以病程。评估变量之间的线性关系,并进行多维分析以确定同质患者组。IMNM患者年龄48.1±15.8岁,病程9.8±8.1岁。受影响最严重的肌肉群位于骨盆股和腰椎区域。无监督分析显示两组患者:轻度病变负荷(15±10%,n=32/42)和重度病变负荷(60±10%,n=10/42: p<0.001),平均病程分别为6.8±6.0年和19.5±5.7年(p<0.0001)。