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cytokine storm

免疫

关键词免疫 临床研究术语 细胞因子风暴

词汇介绍

拓展阅读

解析

cytokine  英  /'saɪtə(ʊ)kaɪn/  美  /'saɪtə,kaɪn/

释    义   n. [细胞] 细胞因子;细胞激素

例    句   That could result in a "cytokine storm" in which the body secretes too many chemicals as it tries to kill offending microorganisms.这可能导致细胞激素风暴,当它试图杀死进攻的微生物时,体内分泌太多化学物质。

 

storm  英  /stɔːm/  美  /stɔːrm/

释    义   n. 暴风雨;大动荡;

               vt. 猛攻;怒骂;

               vi. 起风暴;横冲直撞;狂怒咆哮

例    句   There's a storm coming.暴风雨就要来了。

概述

  细胞因子风暴(cytokine storm)是一种失控的系统性炎症反应过程,特征环节是促炎性细胞因子过度释放,引起严重免疫病理损伤。2003年严重急性呼吸综合征(severe acute respiratory syndrome,SARS)发生之后,开始有更多研究讨论细胞因子风暴在重型病毒性肺炎发病机制中的作用。最新的COVID-19病理解剖报道提示患者发生细胞因子风暴。   细胞因子风暴发生与重型COVID-19临床进程相关

Nrf2 Activator PB125 as a Potential Therapeutic Agent against COVID-19.复制标题

Nrf2激活剂PB125作为一种潜在的抗新型冠状病毒肺炎治疗剂。

发表时间:2020-06-12

影响因子:4.5

作者: McCord JM

期刊:Antioxidants (Basel)

Nrf2 is a transcription factor that regulates cellular redox balance and the expression of a wide array of genes involved in immunity and inflammation, including antiviral actions. Nrf2 activity declines with age, making the elderly more susceptible to oxidative stress-mediated diseases, which include type 2 diabetes, chronic inflammation, and viral infections. Published evidence suggests that Nrf2 activity may regulate important mechanisms affecting viral susceptibility and replication. We examined gene expression levels by GeneChip microarray and by RNA-seq assays. We found that the potent Nrf2-activating composition PB125 downregulates and mRNA expression in human liver-derived HepG2 cells. is a surface receptor and activates the spike protein for SARS-CoV-2 entry into host cells. Furthermore, in endotoxin-stimulated primary human pulmonary artery endothelial cells, we report the marked downregulation by PB125 of 36 genes encoding cytokines. These include IL-1-beta, IL-6, TNF-α, the cell adhesion molecules ICAM-1, VCAM-1, and E-selectin, and a group of IFN-γ-induced genes. Many of these cytokines have been specifically identified in the "cytokine storm" observed in fatal cases of COVID-19, suggesting that Nrf2 activation may significantly decrease the intensity of the storm.

译文

Nrf2是一种转录因子,调节细胞氧化还原平衡和一系列涉及免疫和炎症的基因表达,包括抗病毒作用。Nrf2活性随着年龄的增长而下降,这使得老年人更容易受到氧化应激介导的疾病的影响,包括2型糖尿病、慢性炎症和病毒感染。已有证据表明Nrf2活性可能调节影响病毒易感性和复制的重要机制。我们用基因芯片和rna序列检测基因表达水平。我们发现,强大的nrf2激活成分PB125下调人肝脏来源的HepG2细胞的mRNA表达。是一种表面受体,激活刺突蛋白,使SARS-CoV-2进入宿主细胞。此外,在内毒素刺激的人肺动脉内皮细胞中,我们报道了编码细胞因子的36个基因的PB125显著下调。这些基因包括IL-1-beta、IL-6、TNF- TNF-、细胞粘附分子ICAM-1、VCAM-1和e -选择素,以及一组IFN- tgf诱导的基因。在COVID-19致命病例中观察到的“细胞因子风暴”中,有许多细胞因子被明确识别出来,这表明Nrf2的激活可能会显著降低风暴的强度。