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首页 > 医学词汇大全 > persistent inflammation immunosuppression catabolism syndrome
persistent inflammation immunosuppression catabolism syndrome

免疫

关键词免疫 疾病 持续炎症-免疫抑制-分解代谢综合征

词汇介绍

拓展阅读

解析

persistent  英  /pəˈsɪstənt/  美  /pərˈsɪstənt/

释    义   adj. 执着的,坚持不懈的;持续的,反复出现的;(动植物某部位,如角、叶等)存留的,不落的

例    句   She resented his persistent approaches.她对他没完没了的纠缠极为反感。

 

inflammation  英  /ˌɪnfləˈmeɪʃn/  美  /ˌɪnfləˈmeɪʃn/

释    义   n. [病理] 炎症;[医] 发炎;燃烧;发火

例    句   The drug can cause inflammation of the liver.这种药会引发肝脏炎症。

 

immunosuppression  英  /ˌɪmjunəʊsəˈpreʃn/  美  /ˌɪmjunoʊsəˈpreʃn/

释    义   n. [免疫] 免疫抑制

例    句   The risk of eye damage, premature ageing of the skin and immunosuppression is independent of skin type.眼损伤、皮肤过早老化和免疫抑制等风险与皮肤类型无关。

 

catabolism  英  /kəˈtæbəlɪzəm/  美  /kəˈtæbəlɪzəm/

释    义   n. [生化] 分解代谢

例    句   These processes are called anabolism and catabolism.这些过程叫作合成代谢和分解代谢。

 

syndrome 英  /ˈsɪndrəʊm/  美  /ˈsɪndroʊm/

释    义   n. [临床] 综合症状;并发症状;校验子;并发位

例    句   This syndrome is associated with frequent coughing.这种综合征与经常咳嗽有关。

概述

  持续性炎症、免疫抑制和分解代谢综合征( persistent inflammation immuno-suppression catabolism syndrome,PICS)是由创伤、脓毒症等多种损伤因素导致的,以住院时间长、持续的炎症反应、免疫抑制、蛋白质高分解代谢为特点的一组临床综合征,通常表现为营养不良、反复院内感染,乏力,呼吸机依赖和精神障碍等,病死率较高。   发病机制   PICS的发病机制主要从两个方

Persistent Inflammation, Immunosuppression and Catabolism Syndrome (PICS) after Polytrauma: A Rare Syndrome with Major Consequences.复制标题

多发伤后持续炎症、免疫抑制和分解代谢综合征 (PICS): 一种罕见的具有主要后果的综合征。

发表时间:2020-01-10

影响因子:5.7

作者: Hesselink L

期刊:J Clin Med

Nowadays, more trauma patients develop chronic critical illness (CCI), a state characterized by prolonged intensive care. Some of these CCI patients have disproportional difficulties to recover and suffer from recurrent infections, a syndrome described as the persistent inflammation, immunosuppression and catabolism syndrome (PICS). A total of 78 trauma patients with an ICU stay of ≥14 days (CCI patients) between 2007 and 2017 were retrospectively included. Within this group, PICS patients were identified through two ways: (1) their clinical course (≥3 infectious complications) and (2) by laboratory markers suggested in the literature (C-reactive protein (CRP) and lymphocytes), both in combination with evidence of increased catabolism. The incidence of PICS was 4.7 per 1000 multitrauma patients. The sensitivity and specificity of the laboratory markers was 44% and 73%, respectively. PICS patients had a longer hospital stay (median 83 vs. 40, < 0.001) and required significantly more surgical interventions (median 13 vs. 3, = 0.003) than other CCI patients. Thirteen PICS patients developed sepsis (72%) and 12 (67%) were readmitted at least once due to an infection. In conclusion, patients who develop PICS experience recurrent infectious complications that lead to prolonged hospitalization, many surgical procedures and frequent readmissions.

译文

如今,更多的创伤患者发展为慢性危重症(CCI),一种以延长重症监护时间为特征的状态。一些CCI患者康复困难,并遭受反复感染,这是一种被称为持续性炎症、免疫抑制和分解代谢综合征(PICS)的综合征。回顾性纳入2007 - 2017年住院ICU≥14天的创伤患者78例(CCI患者)。在本组中,通过两种方法确定PICS患者:(1)他们的临床病程(≥3个感染并发症)和(2)通过文献中提示的实验室标记物(c反应蛋白(CRP)和淋巴细胞),两者结合分解代谢增加的证据。PICS的发生率为每1000多创伤患者4.7。实验室标记的敏感性和特异性分别为44%和73%。相比其他CCI患者,PICS患者住院时间更长(中位83 vs. 40, < 0.001),需要更多的手术干预(中位13 vs. 3, = 0.003)。13名PICS患者出现脓毒症(72%),12名患者(67%)至少因感染再次入院一次。总之,患有PICS的患者会经历反复的感染并发症,导致长时间住院,许多外科手术和频繁的再入院。