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首页 > 医学词汇大全 > myelin oligodendrocyte glycoprotein associated diseases
myelin oligodendrocyte glycoprotein associated diseases

免疫

关键词免疫 疾病 髓鞘少突胶质细胞糖蛋白抗体相关疾病

词汇介绍

拓展阅读

解析

myelin 英  /ˈmaɪəlɪn/  美  /ˈmaɪəlɪn/

释    义   n. 髓磷脂(等于 myeline)

例    句   In vitro experiment, BMP-4 suppress oligodendrocyte precursors differentiation into oligodendrocyte and promote the astroglial differentiation.BMP-4在体外可抑制少突胶质前体细胞向少突胶质细胞的分化,并促使其向星形胶质细胞分化。

 

oligodendrocyte  英  /'ɔliɡəu'dendrəsait, ə,liɡəu-/  美  /'ɔliɡəu'dendrəsait, ə,liɡəu-/

释    义   n. 少突细胞

例    句   In vitro experiment, BMP-4 suppress oligodendrocyte precursors differentiation into oligodendrocyte and promote the astroglial differentiation.BMP-4在体外可抑制少突胶质前体细胞向少突胶质细胞的分化,并促使其向星形胶质细胞分化。

 

glycoprotein 英  /,glaɪkə(ʊ)'prəʊtiːn/  美  /,glaɪko'pro,tin/

释    义   n. [生化] 糖蛋白

例    句   Osteopontin is a glycoprotein involved in inflammation, angiogenesis, and metastasis, and has been found in higher levels in cancer patients with metastatic disease.骨桥蛋白是一种参与炎症、血管生成和转移的糖蛋白,研究发现其在发生癌症转移的病人中血中表达水平较高。

 

associated 英  /əˈsəʊsieɪtɪd; əˈsəʊʃieɪtɪd/  美  /əˈsoʊsieɪtɪd,əˈsoʊʃieɪtɪd/

释    义   v. 联系(associate的过去式和过去分词);

               adj. 关联的;联合的

例    句   Salaries and associated costs have risen substantially.薪金与相关费用大大增加。

 

disease  英  /dɪˈziːz/  美  /dɪˈziːz/

释    义   n. 病,[医] 疾病;弊病;

               vt. 传染;使…有病

例    句   The disease spreads easily.这种疾病容易传播。

概述

  髓鞘少突胶质细胞糖蛋白位于中枢神经系统髓鞘和少突胶质细胞的最外层,据报道,以往在多发性硬化和视神经脊髓炎谱系疾病、急性播散性脑脊髓炎、孤立性视神经炎或横断性脊髓炎患者中发现存在MOG抗体。虽然临床和影像学等表现大量重叠,MOG抗体阳性的患者仍表现出独立的特点,近年来逐渐认为他们为一个独立的疾病实体,称为MOG-IgG相关疾病   抗髓鞘少突胶质细胞糖蛋白抗体相关中枢神经系统炎性脱髓鞘病(MOG-IDD)   2007

The impact of regional astrocyte interferon-γ signaling during chronic autoimmunity: a novel role for the immunoproteasome.复制标题

慢性自身免疫过程中区域星形胶质细胞干扰素-γ 信号的影响: 免疫蛋白酶体的新作用。

发表时间:2020-06-12

影响因子:5.7

作者: Smith BC

期刊:J Neuroinflammation

In early autoimmune neuroinflammation, interferon (IFN)γ and its upregulation of the immunoproteasome (iP) is pathologic. However, during chronic multiple sclerosis (MS), IFNγ has protective properties. Although dysregulation of the iP has been implicated in neurodegeneration, its function remains to be fully elucidated. Here, we demonstrate that IFNγ signaling in regional astrocytes induces the iP and promotes protection of the CNS during chronic autoimmunity. In a multiple sclerosis (MS) brain, we evaluated mRNA expression and labeled postmortem MS brainstem and spinal cord for iP subunits and indicators of oxidative stress. Primary regional human astrocytes were analyzed for iP regulation and function by quantitative reverse transcription-polymerase chain reaction (qRT-PCR), Western blot, OxyBlot, and reactive oxygen species and caspase activity detection assays. Following immunization with myelin oligodendrocyte glycoprotein (MOG), the role of IFNγ signaling and the iP during chronic experimental autoimmune encephalomyelitis (EAE) were assessed using pharmacologic inhibition of the iP and genetic interruption of IFNγ signaling specifically in astrocytes.

译文

在早期的自身免疫性神经炎症中,干扰素(IFN)和其上调的免疫蛋白酶体(iP)是病理学的。然而,在慢性多发性硬化(MS)期间,IFN h具有保护作用。虽然iP的失调与神经退行性变有关,但其功能仍有待完全阐明。在此,我们证明了在区域星形胶质细胞中IFN h / h信号诱导iP并促进慢性自身免疫过程中对中枢神经系统的保护。在多发性硬化(MS)大脑中,我们评估mRNA的表达,并标记死后MS脑干和脊髓中的iP亚单位和氧化应激指标。采用定量逆转录-聚合酶链反应(qRT-PCR)、Western blot、OxyBlot、活性氧和半胱天蛋白酶活性检测等方法分析原发性区域性星形胶质细胞的iP调控和功能。在用髓鞘少突胶质细胞糖蛋白(MOG)免疫后,通过在星形胶质细胞中对iP的药理学抑制和IFN缺失信号的遗传中断,评估了IFN缺失信号和iP在慢性实验性自身免疫性脑脊髓炎(EAE)中的作用。