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首页 > 医学词汇大全 > Takayasu Arteritis (TA)
Takayasu Arteritis (TA)

免疫

关键词免疫 疾病 大动脉炎

词汇介绍

拓展阅读

解析

Takayasu

释    义    n.大动脉炎(Takayasu)人名;(日)高安 (姓)

例    句    In Taiwan, reports on the diagnosis of Takayasu arteritis based on MR imaging and MR angiography are rare.但在台湾,使用核磁共振影像及核磁共振血管摄影来诊断高安氏动脉炎的例子不多见。

 

Arteritis    /,ɑːtə'raɪtɪs/  

释    义    n. [内科] 动脉炎

例    句    Headaches in people over 50 can be due to temporal arteritis.年过五旬的人若患上头痛,便可能是由颞动脉炎所致。

概述

大动脉炎是一种累及主动脉及其主要分支以及肺动脉的慢性进行性非特异炎性疾病。疾病由日本医生高安右人(Mikito Takayasu)在1908年首次报告,因此又被称为高安病、Takayasu病。大动脉炎在亚洲地区较多见,多发于年轻女性,男女发病比例约为1:8~9,女性的发病高峰在20岁左右,在30岁以前发病约占90%,40岁以后较少发病,而男性并没有准确的发病年龄高峰。大动脉炎的病因迄今尚不明确,可能与感染引起的免疫损伤或遗传因素等因素有关。 临床表现

Takayasu arteritis: an update复制标题

多发性大动脉炎: 更新

发表时间:2017-01-09

影响因子:3.9

作者: Seyahi E

期刊:Curr Opin Rheumatol

Takayasu arteritis may not be rare disease as recent evidence shows that the disease can be seen in all ethnicities around the world with increasing prevalence rates. The clinical phenotype seems to be affected by ethnicity and gender. The patient should be meticulously evaluated before the pregnancy decision as there is high complication risk for both maternal and fetal health. IBDs frequently coexist with Takayasu arteritis and studies show that the two diseases may have common genetic etiology. Noninvasive tools such as computerized tomography or MR angiography replaced conventional angiography. FDG-PET/CT is now frequently used to assess vascular inflammation. A residual FDG uptake despite clinical remission can be still observed during the follow-up. Recently CEUS of carotid arteries was reported to be useful as a noninvasive method in detecting active vascular inflammation. Biological agents such as anti-TNF agents, tocilizumab, and rituximab could be used effectively in refractory cases. The restenosis or occlusion risks seem to be still high with vascular interventions.The mortality seems to be decreasing in recent years.

译文

高动脉炎可能不是罕见的疾病,因为最近的证据表明,这种疾病可以在世界各地的所有民族中看到,随着发病率的增加。临床表型似乎受种族和性别的影响。在决定怀孕之前,应仔细评估患者,因为这对母婴健康都有很高的并发症风险。IBDS常常与大动脉炎共存,研究表明这两种疾病可能有共同的遗传病因学。非侵入性工具,如计算机断层扫描或磁共振血管造影取代了传统的血管造影。FDG-PET/CT现在常用于评估血管炎症。尽管临床病情缓解,但在随访期间仍能观察到FDG的残留摄取。近年来,颈动脉超声造影(CEUS)被认为是一种无创性检测活动性血管炎症的方法。生物制剂如抗TNF制剂、托西单抗和利妥昔单抗可有效地用于难治性病例。血管介入治疗后再狭窄或闭塞的风险似乎仍然很高,近年来死亡率似乎在下降。