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Overlap Syndrome

免疫

关键词免疫 疾病 重叠综合征

词汇介绍

拓展阅读

解析

Overlap   英 /ˌəʊvəˈlæp/ 美 /ˌoʊvərˈlæp/  

释    义    n. 重叠的部分

例    句    If the ranges overlapped, then both links would be shown at the overlap points. 如果范围有重叠,那么当分数处于重叠部分时,两个链接都显示。

 

Syndrome   英 /ˈsɪndrəʊm/ 美 /ˈsɪndroʊm/

释    义    n. [临床] 综合征;综合症状

例    句    But now the condition, also called "toasted skin syndrome", is being seen in some laptop users.但现在的状况,也叫“烤皮肤综合征”,正出现在一些笔记本电脑用户中。


概述

重叠综合征指的是患有两种或两种以上结缔组织病间病情的重叠,亦称为重叠结缔组织病。结缔组织病的重叠发生通常以传统的几个结缔组织病间最常见,如SLE、硬皮病、皮肌炎和多发性肌炎、类风湿性关节炎、结节性多动脉炎等。也有以其中的一种或二种与其他结缔组织病或自身免疫性疾病发生重叠。如干燥综合征、白塞病、韦格纳肉芽肿病、桥本甲状腺炎、免疫性血小板减少性紫癜、免疫性溶血性贫血、原发性胆汁性肝硬化等发生重叠。重叠综合征的病因尚不清楚,但是主要与免疫功能异常、环境因素和遗传背景相关。

Remodelling of calcinosis cutis in a patient with scleroderma overlap syndrome复制标题

硬皮病重叠综合征患者钙质沉着性皮肤的重塑

发表时间:2020-01-18

影响因子:5.1

作者: Dittmer MR

期刊:J Eur Acad Dermatol Venereo

In calcinosis cutis, calcium salts deposit in skin and soft tissues. Most commonly, tissue micro-injury causes dystrophic precipitation in the face of normal serum calcium and phosphorus levels, and autoimmune connective tissue disease (ACTD) underlies the majority of cases. While a cogent understanding of the pathomechanisms effecting dystrophic calcification in skin remains elusive, mounting data suggest a central role for altered bone metabolism, hypoxia-induced cell signalling and the cytokine milieu promoted by activated macrophages.1 Treatment is challenging, and lesions often remain static despite a slew of therapies tried in the literature. Herein, we present a case of remodelling of calcinosis cutis in the setting of scleroderma overlap syndrome and discuss calcinosis cutis pathophysiology, which bears semblance to mineralization in bone and vasculature.

译文

在皮肤钙质沉着症中,钙盐沉积在皮肤和软组织中。最常见的是,面对正常的血清钙和磷水平,组织微损伤会导致营养不良沉淀,大多数病例的基础是自身免疫性结缔组织病(ACTD)。虽然对影响皮肤营养不良钙化的病理机制的理解仍然是难以捉摸的,但越来越多的数据表明,骨代谢改变、缺氧诱导的细胞信号转导和活化巨噬细胞促进的细胞因子环境具有中心作用。1治疗是具有挑战性的,尽管在文献中尝试了很多治疗方法,但病变通常保持静止。在此,我们提出一个硬皮病重叠综合征背景下皮肤钙质沉着症的重塑病例,并讨论皮肤钙质沉着症的病理生理学,它在骨骼和血管系统中具有矿化的相似性。