Cyclosporine /,saɪklə'spɔrin; ,saɪklə'spɔrɪn; ,saɪklə'sporin/
释 义 n. 环孢霉素（等于cyclosporin）
例 句 Cyclosporine may increase your risk of developing certain types of cancer, including skin cancer.环孢霉素可能增加你患某些癌症的风险，包括皮肤癌。
作者： Petrillo C
期刊：Hum Gene Ther
On these premises, increasing lentiviral vector (LV) transduction efficiencies would ultimately allow not only the amount of vector required for clinically relevant gene transfer to be decreased, but alsothe ex vivo culture time to be shortened, as well as preserving the biological properties of HSPC, critical for safe and efficient therapeutic outcomes. In this regard, a number of immunomodulatory compounds, including rapamycin (Rapa), cyclosporin A (CsA), and more recently cyclosporin H (CsH), have been identified as capable of significantly increasing LV transduction in both human and murine HSPC. This study assessed the efficacy of the improved CsA and Rapa-based shorter transduction protocols in clinically relevant settings using bone marrow (BM)-derived CD34+ cells and clinical-grade vectors, as well as providing insight regarding the effects of CsA on HSPC engraftment in this context.