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首页 > 医学词汇大全 > Cyclosporine A
Cyclosporine A

免疫

关键词免疫 药物 环孢菌素A

词汇介绍

拓展阅读

解析

Cyclosporine    /,saɪklə'spɔrin; ,saɪklə'spɔrɪn; ,saɪklə'sporin/

释    义    n. 环孢霉素(等于cyclosporin)

例    句    Cyclosporine may increase your risk of developing certain types of cancer, including skin cancer.环孢霉素可能增加你患某些癌症的风险,包括皮肤癌。

概述

环孢菌素一种很强的免疫抑制剂,可抑制细胞介质的反应发作,能可逆性抑制T细胞增殖,不抑制血细胞的生成,也不影响吞噬细胞功能,因此与其他抑制剂相比,具有较少诱发或加重感染的优点,临床上主要用于肾、肝、心、肺、骨髓移植的抗排斥反应。   药理作用 环孢菌素具有可逆地选择性地改变T淋巴细胞的功能,阻止淋巴激活素基因的转录,干扰原信息的传递,抑制白细胞介素-2、干扰素和其他免疫因子的释放,影响体液免疫和细胞免疫,抑制NK细胞的杀伤活力;抑制淋

Assessing the Impact of Cyclosporin A on Lentiviral Transduction and Preservation of Human Hematopoietic Stem Cells in Clinically Relevant Ex Vivo Gene Therapy Settings复制标题

在临床相关的体外基因治疗环境中评估环孢菌素A对慢病毒转导和人造血干细胞保存的影响

发表时间:2019-09-05

影响因子:3.9

作者: Petrillo C

期刊:Hum Gene Ther

On these premises, increasing lentiviral vector (LV) transduction efficiencies would ultimately allow not only the amount of vector required for clinically relevant gene transfer to be decreased, but alsothe ex vivo culture time to be shortened, as well as preserving the biological properties of HSPC, critical for safe and efficient therapeutic outcomes. In this regard, a number of immunomodulatory compounds, including rapamycin (Rapa), cyclosporin A (CsA), and more recently cyclosporin H (CsH), have been identified as capable of significantly increasing LV transduction in both human and murine HSPC. This study assessed the efficacy of the improved CsA and Rapa-based shorter transduction protocols in clinically relevant settings using bone marrow (BM)-derived CD34+ cells and clinical-grade vectors, as well as providing insight regarding the effects of CsA on HSPC engraftment in this context.

译文

在这些前提下,提高慢病毒载体(LV)的转导效率,最终不仅可以减少临床相关基因转移所需的载体数量,而且可以缩短体外培养时间,并保持HSPC的生物学特性,对安全有效的治疗结果至关重要。在这方面,一些免疫调节化合物,包括雷帕霉素(Rapa)、环孢菌素a(CsA)和最近发现的环孢菌素H(CsH),被认为能够显著增加人和小鼠HSPC的左室传导。本研究利用骨髓(BM)来源的CD34+细胞和临床级载体,在临床相关环境中评估了改进的基于CsA和Rapa的较短转导方案的疗效,并提供了有关CsA在这方面对HSPC植入的影响的见解。