Interleukin-17 cytokines: Effectors and targets in psoriasis-A breakthrough in understanding and treatment.
Interleukin-17 细胞因子: 银屑病的效应物和靶点-理解和治疗的突破。

摘要

The IL-17 cytokine family comprising IL-17A to IL-17F and receptor subunits IL-17RA to IL-17RE represents a genetically ancient intercellular network regulating local tissue homeostasis. Its pivotal role in antifungal defense and its central position in the pathogenesis of inflammatory diseases including psoriasis were discovered only relatively late in the early 2000s. Since the connection of dysregulated IL-17 and psoriasis pathogenesis turned out to be particularly evident, a number of monoclonal antibodies targeting IL-17 pathways have been approved and are used as first line treatment of moderate-to-severe plaque psoriasis and psoriatic arthritis, and further agents are currently in clinical development.

译文

IL-17 的细胞因子家族包括 IL-17A IL-17F 和 IL-17RA IL-17RE 的受体亚基,代表了一个遗传上古老的细胞间网络,调节局部组织的稳态。它在抗真菌防御中的关键作用及其在包括牛皮癣在内的炎症性疾病发病机制中的中心地位在 21世纪00年代初后期才被发现。由于失调的 IL-17 与牛皮癣发病机制的联系变得尤为明显, 许多靶向 IL-17 通路的单克隆抗体已经被批准,并被用作中重度斑块型牛皮癣和关节炎牛皮癣的一线治疗,进一步的药物目前正在临床开发中。

Psoriasis

免疫 慢性皮肤炎症性疾病 疾病
概述  :  

银屑病即牛皮藓,是一种很难痊愈的慢性皮肤炎症性疾病,患有此病会出现皮肤大面积红斑、鳞屑,但通常不会危及生命,只在皮肤组织发病,不影响内脏,目前的研究也表明银屑病属于良性病变,不会发生癌变。银屑病不是由感染直接导致的,因此不会传染给他人。目前世界各国银屑病的患病率介于0.09%到11.4%之间,其中,东亚人群中发病率较低,北欧人群发病率最高,在挪威银屑病的发病率为11.4%。男女发病率相差不大,但有些研究报告指出,男性出现银屑病的现象更为普遍。 分型及症状

Psoriasis   英 /səˈraɪəsɪs/ 美 /səˈraɪəsɪs/

释义    n. 牛皮癣;银屑病

例句    Green tea is also proven to be highly effective in curing eczema and psoriasis.实践证明绿茶对湿疹和牛皮癣都有显著疗效。

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