摘要

Systemic lupus erythematosus (SLE) is a serious systemic autoimmune disorder that affects multiple organ systems and is characterized by unpredictable flares of disease. Recent evidence indicates a role for type I interferon (IFN) in SLE pathogenesis; however, the downstream effects of IFN pathway activation are not well understood. Here we test the hypothesis that type I IFN-regulated proteins are present in the serum of SLE patients and correlate with disease activity.We performed a comprehensive survey of the serologic proteome in human SLE and identified dysregulated levels of 30 cytokines, chemokines, growth factors, and soluble receptors. Particularly striking was the highly coordinated up-regulation of 12 inflammatory and/or homeostatic chemokines, molecules that direct the movement of leukocytes in the body. Most of the identified chemokines were inducible by type I IFN, and their levels correlated strongly with clinical and laboratory measures of disease activity.These data suggest that severely disrupted chemokine gradients may contribute to the systemic autoimmunity observed in human SLE. Furthermore, the levels of serum chemokines may serve as convenient biomarkers for disease activity in lupus.

译文

系统性红斑狼疮 (SLE) 是一种严重影响多器官系统的全身性自身免疫性疾病,其特征是疾病不可预测的发作。最近的证据表明 I 型干扰素 (IFN) 在 SLE 发病机制中的作用; 然而,IFN 途径激活的下游作用尚不清楚。在这里,我们检验了 I 型干扰素调节蛋白存在于 SLE 患者血清中的假设,并与疾病活动相关。我们对人类 SLE 的血清蛋白质组进行了全面的调查,并确定了 30 种细胞因子、趋化因子、生长因子和可溶性受体的异常调节水平。尤其引人注目的是 12 种炎症和/或稳态趋化因子的高度协调上调,这些趋化因子是指导体内白细胞运动的分子。大多数已鉴定的趋化因子是由 I 型干扰素诱导的,它们的水平与疾病活动的临床和实验室指标密切相关。这些数据表明,严重破坏的趋化因子梯度可能有助于在人类 SLE 中观察到的系统性自身免疫。此外,血清趋化因子的水平可以作为狼疮疾病活动的方便生物标志物。

systemic lupus erythematosus (SLE)

免疫 系统性红斑狼疮 疾病
概述  :  

系统性红斑狼疮是一种自身免疫介导的,以免疫性炎症为突出表现的弥漫性结缔组织病。血清中出现以抗核抗体为代表的多种自身抗体和多系统累及是系统性红斑狼疮的两大主要临床特征。 临床表现 1.全身表现:SLE患者常常出现发热,可能是SLE活动的表现,但应除外感染因素,尤其是在免疫抑制治疗中出现的发热,更需警惕。疲乏是SLE常见但容易被忽视的症状,常是狼疮活动的先兆。 2.皮肤与粘膜:在鼻梁和双颧颊部呈蝶形分布的红斑是

Systemic 英 [sɪˈsti:mɪk; sɪˈstemɪk] 美 [sɪˈstemɪk]

释    义    adj. 系统的;全身的;体系的

例    句    Without a resolution of this global debt burden, systemic risk will fester and grow.没有这个全球债务负担的解决,系统性风险将恶化和生长。

 

Lupus 英 [ˈlu:pəs] 美 [ˈlu:pəs]

释    义    n. 狼疮

例    句    Systemic lupus erythematosus. This chronic inflammatory disease can lead to serious kidney damage.系统性红斑狼疮 这种慢性炎性疾病会严重损害肾功能。

 

Erythematosus 美 [ˌɛrɪθi:məˈtəʊsəs]

释    义    n. 全身性红斑狼疮

adj. 红斑的

例    句    Systemic Lupus Erythematosus, SLE, or just "lupus", is an autoimmune condition that occurs when the body's tissues are attacked by its own T-cells.红斑性狼疮是一种自我免疫系统疾病,因为体内的T淋巴细胞攻击自己身体里正常的组织、而产生的疾病。

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