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vitamin C in sepsis

重症

关键词重症 临床研究术语 脓毒症

词汇介绍

拓展阅读

解析

vitamin 英 /ˈvɪtəmɪn/ 美 /ˈvaɪtəmɪn/  

释义   n. [生化] 维生素;[生化] 维他命

例句   As with any vitamin or supplement, please consult your doctor before taking. 正如任何一种维生素或补品,服用前请咨询你的医生。

 

sepsis 英 /ˈsepsɪs/ 美 /ˈsepsɪs/

释义   n. 败血症,[医] 脓毒病;腐败作用

例句   S. aureus can cause a range of illnesses from minor skin infections to life-threatening diseases, such as pneumonia, endocarditis and sepsis.金黄色葡萄球菌能引起从轻微皮肤感染到危及生命的一系列疾病,如肺炎、心内膜炎和败血症。

概述

2016年拯救脓毒症运动国际指南委员会将脓毒症定义为因感染引起宿主反应失调而导致危及生命的器官功能障碍。现有研究表明,重症监护病房(ICU)患者脓毒症的发病率为37.3%,其中9.2%的患者发展为脓毒性休克,后者的病死率高达42.7%,是危重病患者常见的并发症之一,亦是一个重大的公共卫生问题。目前关于脓毒症的治疗主要包括控制感染源、抗感染药物、液体复苏、血管活性药物等支持治疗,虽经过大量治疗方法的探索与实践,但脓毒症病死率并无明显降低,寻找新的辅助疗法以改善脓毒症患

Vitamin C for the treatment of sepsis: The scientific rationale复制标题

维生素c治疗脓毒症: 科学原理

发表时间:2018-09-15

影响因子:9.4

作者: Marik PE

期刊:Pharmacol Ther

Ascorbic acid, also known as vitamin C, has played a unique role in the history of medicine. Scurvy is an ancient disease, being one of the most dreaded and devastating plagues of history. The earliest written reference to a condition that is recognizable as scurvy is in the Ebers papyrus, a record of Egyptian medical lore written in 1500 BC. Clinical reports dating back to Hippocrates have provided a comprehensive picture of the disease . The Renaissance witnessed several epidemics of scurvy among sea voyagers. Sir James Lind, a Scottish Naval surgeon is credited with correct identification of the protective and therapeutic properties of citrus fruits, specifically oranges and lemons. In 1647 he conducted a randomized controlled study (the first in the history of medicine) in 12 scorbutic sailors divided into six groups of two individuals. Each group were treated with a different remedy. In his published treatise, Lind concluded that citrus fruits were the most effective treatment for scurvy . Over 30 000 cases of scurvy were reported in the American Civil War and it took the U.S Army until 1895 to adopt antiscorbutic measures.

译文

抗坏血酸,也称为维生素C,在医学史上起着独特的作用。坏血病是一种古老的疾病,是历史上最可怕和最破坏性的灾难之一。最早被认为是坏血病的书面记载是在埃伯斯纸莎草纸上,这是公元前1500年写的埃及医学传说的记录。可以追溯到希波克拉底的临床报告提供了对该疾病的全面描述。文艺复兴时期目睹了海上航海家中数种坏血病的流行。苏格兰海军外科医生詹姆斯·林德爵士(Sir James Lind)可以正确识别柑橘类水果(尤其是橙子和柠檬)的保护和治疗特性。在1647年,他对12名受虐儿童进行了随机对照研究(这是医学史上的第一项研究),分为六组,每组两个人。每组均接受不同的治疗。 Lind在发表的论文中得出结论,柑橘类水果是治疗坏血病最有效的方法。在美国内战中报告了超过3万例坏血病病例,直到1895年,美军才采取了反腐败措施。