colistin 英 /kə'lɪstɪn/ 美 /kə'lɪstɪn/
释义 n. [药] 粘菌素（用于治疗肠胃炎）
例句 Despite being administered colistin, a powerful antibiotic, the patient died, the doctor said.医生表示，已经给患者使用了药性极强的黏菌素抗生素，仍未能挽回他的生命。
作者： Grégoire N
In this review, we provide an updated summary on colistin pharmacokinetics and pharmacodynamics.Colistin is an old molecule that is frequently used as lastline treatment for infections caused by multidrug-resistant Gram-negative bacteria. Colistin is a decapeptide administered either as a prodrug, colistin methanesulfonate (CMS), when used intravenously, or as colistin sulfate when used orally. Because colistin binds to laboratory materials, many experimental issues are raised and studies on colistin can be tricky. Due to its large molecular weight and its cationic properties at physiological pH, colistin passes through physiological membranes poorly and is mainly distributed within the extracellular space. Renal clearance of colistin is very low, but the dosing regimen should be adapted to the renal function of the patient because CMS is partly eliminated by the kidney.