Salmonella-mediated tumor therapy angiogenesis. melanoma neutrophils
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摘要

The weakened tumour colonization of attenuated Salmonella has severely hampered its clinical development. In this study, we investigated whether an anti-inflammation and antiangiogenesis compound triptolide could improve the efficacy of VNP20009, a highly attenuated Salmonella strain, against mice melanoma. By comparing the effects of conventional VNP20009 monotherapy and a combination therapy that uses both triptolide and VNP20009, we found that triptolide significantly improved the tumour colonization of VNP20009 by reducing the number of infiltrated neutrophils in the melanoma, which led to a larger necrotic area in the melanoma. Moreover, the combination therapy suppressed tumour angiogenesis by reducing the expression of VEGF in a synergistic manner, retarding the growth of the melanoma. Our study revealed that triptolide could significantly enhance the antitumour effect of VNP20009 by modulating tumour angiogenesis and the host immune response, providing a new understanding of the strategy to improve Salmonella-mediated tumour therapy.

译文

减毒沙门氏菌 colonization 定植能力减弱,严重阻碍了其临床发展。在这项研究中,我们研究了抗炎和抗血管生成化合物雷公藤甲素是否能提高 VNP20009 (一种高度减毒的沙门氏菌株) 对小鼠黑色素瘤的疗效。通过比较传统的 VNP20009 单一疗法和同时使用雷公藤内酯醇和 VNP20009 的联合疗法的效果, 我们发现雷公藤内酯醇通过减少黑素瘤中浸润中性粒细胞的数量,显著改善了 VNP20009 的肿瘤定植,从而导致黑素瘤中更大的坏死区域。此外,联合疗法通过协同减少 VEGF 的表达抑制肿瘤血管生成,延缓黑素瘤的生长。我们的研究显示,雷公藤内酯醇可以通过调节肿瘤血管生成和宿主免疫反应显著增强 VNP20009 的抗肿瘤作用,为改善沙门氏菌介导的肿瘤治疗策略提供了新的理解。

Triptolide

重症 雷公藤甲素 药物
概述  :  

雷公藤甲素(triptolide,TP),又称雷公藤内酯、雷公藤内酯醇,是从雷公藤中分离出的环氧化二萜内酯化合物,也是中药雷公藤的主要活性成分之一。雷公藤甲素分子式为C20H24O6,相对分子质量为360。 目前雷公藤提取物制剂“雷公藤多甙片”已成功上市,其包含雷公藤甲素等多种雷公藤活性成分,可祛风解毒、除湿消肿、舒筋通络等,常被用于治疗类风湿性关节炎、肾病综合征、自身免疫性肝病等疾病。   作用机制 1.抑制肿瘤生

triptolide

释义   雷公藤甲素

例句   Objective It is to study the inducing H22 cell apoptosis action of triptolide.目的研究雷公藤甲素对H22细胞的诱导凋亡作用。

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