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Influence of coupled hemodynamics-arterial wall interaction on compliance in a realistic pulmonary artery with variable intravascular wall properties.
血流动力学-动脉壁耦合相互作用对具有可变血管内壁属性的现实肺动脉顺应性的影响。
Artery wall pre-stress Cardiac MRI Cardiovascular FSI Pulmonary hypertension
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摘要

Pulmonary hypertension is characterized by elevation of pulmonary artery (PA) pressure (p) and structural remodeling of the PA wall, leading to reduction in arterial compliance (c). As a step towards improving diagnosis of pulmonary disease, we use the PA branch geometry (main pulmonary artery (MPA) branching into left (LPA) and right (RPA) pulmonary arteries) obtained from MRI in conjunction with an inverse algorithm to obtain the pre-stress level in the artery walls. Next, a coupled blood-wall interaction (BWI) calculation provides hemodynamic information as well as compliance of the PA walls. We show that the computed load-free geometry from the inverse algorithm exhibits a 27.8% lower inner diameter (d) and 18.5% lower outer d compared to the in vivo geometry from MRI. Further, the mean p computed from the BWI computation in the main PA (pMPA-n) is within 4% of the mean pMPA-e (n-numerical; e-experimental). Also, the mean Q computed in the left PA (QLPA-n) is within 10% of the mean QLPA-e. Finally, the compliance cMPA-n is computed to be 27% lower than cMPA-e, while the cLPA-n is computed to be 20.4% lower than cLPA-e. Importantly, the PA shows significant intra-vascular variation in compliance, with the MPA showing higher overall compliance compared to the LPA (3.5-4 times).

译文

肺动脉高压的特征是肺动脉 (PA) 压力 (p) 的升高和 PA 壁的结构重塑,导致动脉顺应性 (c) 的降低。作为提高肺部疾病诊断的一步,我们使用 PA 分支几何 (主肺动脉 (MPA) 分支左 (LPA) 和右 (RPA) 肺动脉) 通过 MRI 结合反向算法获得动脉壁的预应力水平。接下来,耦合血壁相互作用 (BWI) 计算提供了血流动力学信息以及 PA 壁的顺应性。我们表明,与 MRI 的体内几何结构相比,反向算法计算出的无负载几何结构显示出内径 (d) 低 27.8%,外径低 18.5%。此外,从主 PA (pMPA-n) 中的 BWI 计算中计算的平均 p 在 pMPA-e (n-数值; e-实验) 的 4% 以内。同样,在左 PA (QLPA-n) 中计算的平均 Q 在平均 QLPA-e 的 10% 以内。最后,计算出的柔度 cMPA-n 比 cMPA-e 低 27%,而计算出的 cLPA-n 比 cLPA-e 低 20.4%。重要的是,PA 显示出显著的血管内顺应性变化,与 LPA 相比,MPA 显示出更高的总体顺应性 (3.5-4 倍)。

Hemodynamics

重症 血流动力学 临床研究术语
概述  :  

血流动力学是研究血液及其组成成分在机体内运动特点和规律的科学。与监测不同,血流动力学治疗以血流动力学理论为基础,根据机体实时状态和反应,进行以目标为导向的定量治疗。血流动力学治疗不限于休克,而涉及重症治疗从病因到预后的全过程。随着临床信息量的快速增加、诊断准确程度不断提高,血流动力学理论及指标已成为规范临床行为,控制病程发展不可或缺的策略和方法。   作用机制 血流的动力不仅来源于心脏,亦来自于血管系统。血管内容量分为张

hemodynamics [,hɛmodaɪ'næmɪks]

释义   n. [生理][基医][生物物理] 血液动力学(等于haemodynamics)

例句   Objective:To study the complete process of portal hypertensive emersion, development and maintenance by dynamic view of the changes of hemodynamics.目的:通过动态观察血流动力学的变化,探讨门静脉高压发生、发展和维持的全过程。


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